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Korean Journal of Obstetrics & Gynecology 2007;50(1):85-92.
Published online January 1, 2007.
Relationship between spontaneous preterm birth and polymorphisms of Interleukin-1beta and Interleukin-1 receptor antagonist in Korean women.
Se Ryun Kim, Young Jun Park, Ki Young Ryu, Jong Wook Kim, Eun Seob Song, Byung Ick Lee
1Department of Obstetrics & Gynecology, Kwandong University, Myongji Hospital, Korea. bluebell@kwandong.ac.kr
2Department of Obstetrics & Gynecology, Inha University Hospital, Korea.
Abstract
OBJECTIVE
Preterm birth is an important cause of infant death and morbidity but its pathophysiology still remains to be clear. The associations between preterm birth and the polymorphism of interleukin-1beta gene and interleukin-1 receptor antagonist gene have been suspected. And ethnic variations in the polymorphism of the genes were also reported. We decided to study polymorphisms of interleukin-1beta+3953 and interleukin-1 receptor antagonist in Korean pregnant women. METHODS: Patients were divided into 2 groups. Group 1 is the control group of 33 subjects with uncomplicated term delivery : group 2 is the case group of patients who had spontaneous preterm delivery. Polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism analysis. RESULTS: There were significant differences in gestational age and birth weight between two groups (P<0.001). No significant differences were found in genotypic frequencies and allelic frequencies in interleukin-1beta+3953 between two groups. Interleukin-1 receptor antagonist gene had 5 alleles and the most frequent allele was IL1RN*1 (410bp), 66.7% in control group and 77.8% in case group. And significant differences were not found in genotypic frequencies and allelic frequencies between two groups, too. CONCLUSION: There were no significant differences in polymorphisms in interleukin-1beta +3953 and interleukin-1 receptor antagonist between term delivery group and preterm birth group.
Key Words: preterm birth, polymorphism, interleukin-1beta, interleukin-1 receptor antagonist


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