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Korean Journal of Obstetrics & Gynecology 2002;45(6):926-931.
Published online June 1, 2002.
The relationship between interleukin-1 receptor antagonist gene polymorphism and bone mineral density in postmenopausal Korean women.
Jung Gu Kim, Seok Hyun Kim, Young Min Choi, Shin Yong Moon, Jin Yong Lee
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
To investigate the relationship between polymorphism in interleukin-1 receptor antagonist (IL-1ra) gene and bone mineral density (BMD) in postmenopausal Korean women. METHODS: The 86-base pair repeat polymorphism in the IL-1ra gene was examined by polymerase chain reaction (PCR) and electrophoresis in 285 postmenopausal Korean women. Serum bone alkaline phosphatase (BAP) and CrossLaps (CTX) were measured by immunoassay and BMD at the lumbar spine and proximal femur by dual energy X-ray absorptiometry. RESULTS: Four alleles in IL-1ra gene were identified; A1 (4 repeats), A2 (2 repeats), A3 (5 repeats), A4 (3 repeats). BMD at the lumbar spine, femoral neck, and trochanter in women carrying A2 allele was significantly lower, compared with noncarriage of that allele. Serum BAP levels in the former group were higher than those in the latter group, but no difference in serum CTX levels between two groups was observed. There were no differences in the distribution of IL-1ra A2 allele among normal, osteopenic, and osteoporotic postmenopausal women. CONCLUSIONS: BMD are associated with a polymorphism in IL-1ra gene in postmenopausal Korean women.
Key Words: Postmenopausal women, IL-1ra, polymorphism, BMD

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