| The relationship between T869C polymorphism of transforming growth factor- 1 (TGF- 1) gene and bone mineral density in postmenopausal Korean women. |
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Jung Gu Kim, Seok Hyun Kim, Young Min Choi, Shin Yong Moon, Jin Yong Lee |
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Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. |
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| Abstract |
OBJECTIVE
To investigate the relationship between the T869C polymorphism of transforming growth factor- 1 (TGF- 1) gene, serum TGF- 1 levels and bone mineral density (BMD) in postmenopausal Korean women. METHODS: The T869C polymorphism of TGF- 1 gene was analyzed by allele specific polymerase chain reaction (PCR) and electrophoresis in 296 postmenopausal Korean women. Serum bone alkaline phosphatase (BAP), CrossLaps (CTX), and TGF- 1 were measured by immunoassay, and enzyme linked immunosorbent assay respectively. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry. RESULTS: The frequencies of the TT, TC, and CC genotypes of the T869C polymorphism were 3.3%, 93.7%, and 2.3%. There were no significant differences in BMD of the lumbar spine and proximal femur or serum BAP and CTX levels across the three TGF- 1 genotypes. No significant differences in the distribution of TGF- 1 genotypes and serum TGF- 1 levels among normal, osteopenic, and osteoporotic postmenopausal women were observed. There was no relationship between serum TGF- 1 levels and BMD at the lumbar spine and proximal femur. CONCLUSIONS: The T869C polymorphism of TGF- 1 gene is not associated with serum TGF- 1 levels and BMD in postmenopausal Korean women. |
| Key Words:
Postmenopausal women, TGF- 1, T869C polymorphism, BMD |
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