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Korean Journal of Obstetrics & Gynecology 2002;45(10):1765-1769.
Published online October 1, 2002.
Feasibility of FDG-PET Scan before Second Look Operation in Patients with Ovarian Cancer.
Won Ho Jung, Mu Sam Kang, Chun Suk Park, Mun Hong Kim, Sung Il Kim, Seok Chul Choi, Sang Young Ryu, Kyung Hee Lee
Department of Obstetrics and Gynecology, Korea Cancer Center Hospital, Seoul, Korea.
Abstract
OBJECTIVE
This study is to investigate whether Positron Emission Tomography (PET) is useful for determining pathologic complete response in patients with ovarian carcinoma who had a clinical complete response after primary treatment. METHODS: FDG-PET scans were performed in 10 patients with advanced ovarian cancer (4 patients with stage IIC, 6 patients with IIIC), who showed complete response with cytoreductive surgery and 6 cycles of post-operative adjuvant Cisplatin-based combination chemotherapy. FDG-PET scan was obtained with GE Advance Scanner, beginning at 50 minutes after injection of 370-555 MBq (10-15 mCi) of 18F FDG. Uptakes exceeding 3.5 SUV (Standardized Uptake Value) or larger than surrounding tissue were determined as a positive findings. Second-look laparotomy was undertaken within median 4 days after FDG-PET scanning. RESULTS: The mean age of the patients was 45 years and serous cystadenocarcinoma was most common histologic type. None showed active lesion in pelvis or abdomen with FDG-PET scan (SUV: >3.5 kg/ml), however, 5 patients (50%) showed residual tumors on multiple biopsy during second look operation. One patient showed positive lesion in lung on FDG-PET scan, which was confirmed to have metastatic lesion. CONCLUSION: FDG-PET scan is not useful for detection of small ovarian cancer lesions in pelvis and abdomen and cannot substitute for second-look operation to determine pathologic complete response.
Key Words: FDG-PET scan, Ovarian carcinoma, Second-look operation


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