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Korean Journal of Obstetrics & Gynecology 2007;50(1):167-172.
Published online January 1, 2007.
The usefulness of ovarian volume using 3D VOCAL transvaginal ultrasound, antral follicle count and age as predictors of menopause in pre- and postmenopausal women.
Yoon Sook Kim, Seob Jeon, Jong Su Kim, Seung Do Choi, Jae Gun Sunwoo, Young Woo Shin, Dong Han Bae
1Department of Obstetrics & Gynecology, Soonchunhyang Chunan Hospital, College of Medicine, Soonchunhyang University, Chunan, Korea. drsook@schch.co.kr
2Cheju National university Hospital, Korea.
Abstract
OBJECTIVE
To evaluate the sensitivity and specificity of ovarian volume using 3D VOCAL and 2D ultrasound, antral follicle count, and age as predictors of menopausal status in pre- and postmenopausal women. METHODS: The subjects of this study were premenopausal (n=38) and postmenopausal (n=23) healthy women aged between 35 and 57 years of age who were interviewed about social, demographic, and medical conditions. These women underwent transvaginal ultrasound using 3D VOCAL and 2D probe to determine ovarian volume. Chi-square test was applied to evaluate the correlation between ovarian volume, antral follicle count, age and menopausal status. Receiver operating Characteristic (ROC) curves were elaborated to evaluate the sensitivity, specificity and positive and negative predictive values. RESULTS: Premenopausal women presented larger ovaries than postmenopausal women (p<0.01). Premenopausal women had a higher number of antral follicles than postmenopausal women (p<0.01). ROC curves showed that antral follicle count and ovarian volume using 3D VOCAL transvaginal probe were more sensitive and specific markers of menopausal status than age or ovarian volume using 2D transvaginal probe. CONCLUSIONS: Ovarian volume and antral follicle count differ according to age in pre- and postmenopausal women. The data suggest that antral follicle count and ovarian volume using 3D VOCAL transvaginal probe are quite useful in predicting menopausal status.
Key Words: 3D VOCAL ultrasonography, Menopause, Ovarian volume, Antral follicle count


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