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Obstet Gynecol Sci > Volume 55(2); 2012 > Article
Korean Journal of Obstetrics & Gynecology 2012;55(2):89-97.
DOI: https://doi.org/10.5468/KJOG.2012.55.2.89    Published online February 1, 2012.
Anti-Mullerian hormone, follicle-stimulating hormone, antral follicle count, and clinical findings as predictive markers of menopause in late reproductive-aged women.
Sun Mie Kim, Seok Hyun Kim, Jung Ryeol Lee, Byung Chul Jee, Chang Suk Suh, Joong Yeup Lee, Ki Chul Kim, Do Yeong Hwang, Jung Gu Kim, Shin Yong Moon
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. seokhyun@snu.ac.kr
2Seoul National University Hospital Health Care System Gangnam Center, Seoul, Korea.
3Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
4Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
5Hamchoon Women's Clinics, Seoul, Korea.
Abstract
OBJECTIVE
To assess the efficiency of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC), endometrial thickness (EMT), and clinical findings as predictive markers of menopause in late reproductive-aged Korean women. METHODS: A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2. RESULTS: Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed significantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were significantly associated with the occurrence of menopause. CONCLUSION: This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.
Key Words: Menopausal transition period, Anti-Mullerian hormone, Follicle stimulating hormone, Antral follicle count, Last menstrual period


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