Treatment of gestational diabetes diagnosed by the IADPSG criteria decreases excessive fetal growth

Article information

Obstet Gynecol Sci. 2020;63(1):19-26
Publication date (electronic) : 2019 December 20
doi : https://doi.org/10.5468/ogs.2020.63.1.19
1Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
2Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
3Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea.
4Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
5Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
6Department of Internal Medicine, Institute of Health and Environment, Seoul National University, Seoul, Korea.
7Department of Obstetrics and Gynecology, MizMedi Hospital, Seoul, Korea.
Corresponding author: Minhyoung Kim, MD, PhD. Department of Obstetrics and Gynecology, MizMedi Hospital, 295 Gangseo-ro, Gangseo-gu, Seoul 07639, Korea. obdrmhk@naver.com
Received 2019 March 04; Revised 2019 May 23; Accepted 2019 June 25.

Abstract

Objective

We evaluated the effect on treatment using the new International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria for gestational diabetes mellitus (GDM) diagnosis.

Methods

Singleton pregnant women whose plasma glucose levels were ≥140 mg/dL on the 50 g glucose challenge test (GCT) underwent 75 g oral glucose tolerance for GDM diagnosis. During the first half of the study period, GDM was diagnosed using 2 abnormal values by Carpenter-Coustan (C-C) criteria. In the second half of the study period, 1 or more abnormal values by IADPSG criteria were used for GDM diagnosis. Pregnant women were classified into 5 groups: normal 50 g GCT, positive 50 g GCT but non-GDM, GDM by IADPSG criteria and non-treated, GDM by IADPSG criteria and treated, GDM by C-C criteria and treated. The odds ratios (ORs) for large for gestational age (LGA) and macrosomia were analyzed.

Results

Of the 2,678 patients, the frequency of GDM diagnosed by C-C and IADPSG criteria was 2.6% and 7.5%. ORs (95% confidence intervals [CIs]) for LGA and macrosomia in the group with GDM by IADPSG criteria and non-treated were 2.81 (95% CI, 1.47–5.38) and 2.84 (95% CI, 1.08–7.47). The risk of LGA and macrosomia did not increase in the group with GDM by IADPSG criteria and treated.

Conclusion

The risk of LGA and macrosomia for mild GDM diagnosed solely by IADPSG criteria depends on whether they are treated or not. Treatment of GDM based on IADPSG criteria reduces the risk of excessive fetal growth.

Trial Registration

Clinical Research Information Service Identifier: KCT0000776

Introduction

In 1964, O'Sullivan and Mahan [1] proposed specific criteria for gestational diabetes mellitus (GDM), developed to anticipate type 2 diabetes in mothers after delivery. Based on their diagnostic criteria, there are different glucose cut-offs and strategies to diagnose GDM [2]. In order to reach a consensus in the diagnostic method for GDM and focus on pregnancy complications, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study was conducted [3]. In 2010, based on the HAPO study results, the International Association of Diabetes and Pregnancy Study Group (IADPSG) suggested a universal screening for GDM by 1-step 75 g oral glucose tolerance tests (OGTTs) with new cut-off values [4].

The new IADPSG recommendation diagnosed GDM with only 1 abnormality in the cut-off values. As a consequence, more women who had mild hyperglycemia were diagnosed with GDM. The World Health Organization and the American Diabetes Association have adopted this new recommendation [56]. However, because of the higher incidence of GDM (18% in the U.S.) and little evidence of cost-effectiveness of the new criteria, the American College of Obstetrician and Gynecologists continues to endorse a 2-step approach and diagnostic test by 100 g OGTT [7].

Since the new recommendation of the IADPSG, several studies reported that treatment based on the IADPSG criteria improved pregnancy outcomes. However, those studies were retrospective, and the comparison groups were women with normal glucose tolerance or GDM determined through different glucose cut-off values or diagnostic methods, such as 100 g OGTT [8910]. A recent study reported that no differences were noted between untreated and treated patients diagnosed by the IADPSG criteria [11]. Furthermore, evidence of improvements in perinatal outcomes of the treatment of milder GDM by the IADPSG criteria is still limited. We prospectively evaluated the perinatal outcomes in patients with GDM by the new strict cut-offs of the IADPSG, whether they were treated or not.

Materials and methods

From March 2013 through November 2017, we collected a prospective cohort composed of singleton pregnant women in a single institution. Women with multiple gestations, women who gave birth in another hospital, and women who underwent a diagnostic OGTT at other clinics were excluded.

Our institution diagnosed GDM through a 2-step method. All women were universally screened with a 1-hour, 50 g glucose challenge test (GCT) between 24 and 28 gestational weeks. Women with positive screening (glucose ≥140 mg/dL) underwent a 2-hour 75 g OGTT for GDM diagnosis.

We divided the study period into 2 sub-periods and applied different diagnostic criteria for GDM. During the first 2 years (March 2013 to December 2015), we diagnosed GDM based on 2 or more values exceeding the Carpenter-Coustan (C-C) thresholds [12]. In the following 2 years (January 2016 to November 2017), we diagnosed GDM based on 1 or more values exceeding the new IADPSG thresholds [4]: fasting ≥92 mg/dL, 1-hour ≥180 mg/dL, and 2-hour ≥153 mg/dL. Among the study subjects belonging to the first sub-period of the study, some women were classified as normal and not treated when the new IADPSG thresholds were applied. All women diagnosed with GDM during the 2 study periods received the same management, including diet, exercise, self-monitoring of glucose levels 4 times daily, and, if necessary, insulin therapy.

The study population was categorized in 5 groups: group 1, negative result in 50 g GCT; group 2, positive result in 50 g GCT but normal in 75 g OGTT; group 3, GDM diagnosed by IADPSG criteria and non-treated; group 4, GDM diagnosed by IADPSG criteria and treated; group 5, GDM diagnosed by C-C criteria and treated. The 5 groups did not overlap. Women in groups 3 and 4 had only 1 abnormal value by IADPSG criteria or 2 or more abnormal values belonging to the following levels: fasting glucose at 92–94 mg/dL, 1-hour glucose ≥180 mg/dL, and 2-hour glucose at 153–154 mg/dL.

Data recorded from the pregnant women included age, parity, body mass index (BMI) pre-pregnancy, smoking and alcohol intake pre-pregnancy, family history of diabetes mellitus, and total gestational weight gain (GWG).

The perinatal outcomes included gestational weeks at delivery, birthweight of neonate, cesarean delivery, preterm delivery (<37 completed weeks), large for gestational age (LGA; ≥90th percentile), macrosomia (≥4.0 kg), small for gestational age (SGA; <10th percentile), shoulder dystocia, birth tract laceration of third degree or more, Apgar score, admission to neonatal intensive care unit (NICU), neonatal intubation, and phototherapy for neonatal jaundice. Birth weight criteria used for defining LGA and SGA were based on Korean data [13].

The χ2 test and analysis of variance (ANOVA) were utilized for the comparison of variables. The Tukey test was used for post hoc testing of ANOVA. Multivariate logistic regression analysis was used to identify the odds ratios (ORs) of the different GDM groups for the risk of adverse outcomes while adjusting for potential confounders. The reference group was women with negative results in 50 g GCT. SAS version 9.4 (SAS Institute, Cary, NC, USA) was used for statistical analysis.

Results

A total of 2,678 pregnant women were included in this cohort. Of those, 1,979 (73.9%) women had negative results in the 50 g GCT. Of the 699 women with positive results in the 50 g GCT, 70 (2.6%) had 2 abnormal values by C-C criteria and received treatment (Fig. 1). During the first half of the study period, 52 women (1.9%) who had 1 or more abnormal values by the IADPSG cut-off values, not C-C criteria, were diagnosed as non-GDM and did not receive treatment. During the second half of the study period, 79 women (3.0%) were diagnosed solely by IADPSG criteria as GDM and received treatment. The frequency of GDM diagnosed by IADPSG criteria in our study population was 7.5%.

Fig. 1

Enrollment of study population.

GCT, glucose challenge test; C-C, Carpenter-Coustan; IADPSG, International Association of Diabetes and Pregnancy Study Group; GDM, gestational diabetes mellitus.

The maternal age was significantly younger in the negative 50 g GCT group (Table 1). The BMI was significantly higher in groups with GDM by either IADPSG or C-C criteria. The GWG of women diagnosed with GDM by IADPSG or C-C criteria and treated was significantly lower than that of non-GDM women. Maternal characteristics were not different between treated and not-treated women diagnosed with GDM by IADPSG criteria.

Maternal characteristics of the study population

Each blood glucose value in the 75 g OGTT of women diagnosed with GDM by C-C criteria (fasting glucose 95.0±12.2 mg/dL, 1-hour glucose 194.8±24.2 mg/dL, 2-hour glucose 170.1±25.6 mg/dL) was significantly higher than that of women diagnosed with GDM by IADPSG criteria and treated (fasting glucose 87.1±7.1 mg/dL, 1-hour glucose 166.3±22.4 mg/dL, 2-hour glucose 148.2±19.4 mg/dL) (P<0.001). No difference was noted between each blood glucose level in the 75 g OGTT between treated and not-treated women diagnosed with GDM by IADPSG criteria.

Table 2 shows the perinatal outcomes of the study population. The mean birthweight of neonates was highest in women diagnosed with GDM by IADPSG criteria and not treated, and this was significantly different from neonatal birthweight of the negative 50 g GCT group. The rate of LGA was also highest in women diagnosed with GDM by IADPSG criteria and not treated. The rate of macrosomia was highest in women diagnosed with GDM by C-C criteria and treated, followed by that of women diagnosed with GDM by IADPSG criteria and not treated. The rate of cesarean section was also highest in women diagnosed with GDM by C-C criteria and treated. The rates of SGA and other perinatal outcomes were not different among the 5 groups.

Pregnancy outcomes of 5 groups classified by the results of screening and diagnosis of gestational diabetes mellitus (GDM) by different criteria and treatment

In order to evaluate whether the treatment of GDM diagnosed by IADPSG criteria independently affects perinatal outcomes, we performed multivariate logistic regression analysis after adjusting for age, parity, and BMI pre-pregnancy (Table 3). The risk of macrosomia was increased in women diagnosed with GDM by C-C criteria and treated (OR, 2.61; 95% confidence interval, 1.11–6.14). Women diagnosed with GDM by IADPSG criteria and non-treated showed significantly higher ORs of LGA, macrosomia, and preterm delivery. However, the women diagnosed with GDM by IADPSG criteria and treated did not increase the risk of LGA, macrosomia, and preterm delivery but they had an increased risk of a low Apgar score at 5 minutes and neonatal intubation.

Multivariate logistic regression analysis for the association of gestational diabetes mellitus (GDM) treatment by different criteria and risk of pregnancy outcomes

Discussion

This study evaluated the perinatal complications in GDM by the new strict cut-offs of diagnostic criteria, whether they were treated or not. Here, the treatment of women with GDM diagnosed by IADPSG criteria showed similar pregnancy outcomes compared with women with normal pregnancies. In contrast, the non-treatment of GDM diagnosed by IADPSG criteria independently increased the risk of LGA, macrosomia, and preterm birth. GDM diagnosed by C-C criteria, i.e., higher glucose values in OGTT, also showed an increased risk of macrosomia, although it was treated.

Prior to the HAPO study, there had been reports of treatment of mild GDM reducing pregnancy complications, such as fetal overgrowth and cesarean section [1415]. Those studies applied 2-step approaches and used different OGTTs for the diagnosis of GDM. Crowther et al. diagnosed mild GDM by a fasting glucose <140 mg/dL and 2-hour glucose after a 75 g loading, 140–198 mg/dL [14]. Another study defined mild GDM by a fasting glucose level <95 mg/dL and 2 or more abnormal values in a 3-hour 100 g OGTT: 1-hour, 180 mg/dL; 2-hour, 155 mg/dL; and 3-hour, 140 mg/dL [15]. Those studies treated women who had lower glucose levels than the original cut-off values for GDM diagnosis [1]. The HAPO researchers focused on pregnancy complications and suggested lower diagnostic criteria because of increased pregnancy complications in proportion to the blood glucose levels of OGTT. In our study, each blood glucose level in a 2-hour 75 g OGTT of GDM diagnosed by IADPSG criteria was lower than that of GDM diagnosed by C-C criteria and, notably, the fasting glucose levels were below 90 mg/dL. However, the risk of pregnancy complications including LGA, macrosomia, and preterm delivery was increased if the women were not treated. Our findings complement the HAPO results. A retrospective study also reported that an untreated group of women diagnosed with GDM by IADPSG criteria had a higher birthweight and LGA than a normal group [16]. In addition to the association between mild hyperglycemia and perinatal complications similar to the HAPO results, our data showed that the treatment of mild hyperglycemia reduced LGA and macrosomia.

Since the IADPSG proposal of new criteria for GDM diagnosis, several studies comparing the IADPSG criteria with older C-C or National Diabetes Data Group (NDDG) criteria have reported improved pregnancy outcomes with increased cost savings, while others did not. Duran et al. [17] assessed the cost-benefits between 1-step IADPSG and 2-step C-C methods. The 1-step IADPSG method resulted in a higher GDM diagnosis (35.5% vs. 19.6%, respectively) but improved the pregnancy outcomes of gestational hypertension, preterm birth, cesarean section, and LGA. The estimated saved costs were €14,358 per 100 women. Another study in Asia compared the intervention outcomes between the IADPSG and NDDG criteria [18]. The intervention of GDM according to the IADPSG lowered pregnancy complications compared to NDDG. In contrast, a retrospective study in the U.S. reported that 1-step screening with the IADPSG criteria did not decrease the number of LGA or macrosomic neonates but increased the rate of primary cesarean delivery [19]. In their study, the prenatal BMI of that study population was 26.1 kg/m2, higher than the BMI (22.9 kg/m2) of our population. Obesity in pregnant women is also well-known risk factor for many pregnancy complications and it may lessen the effects of treatment of mild hyperglycemia. In our study, even after adjusting for maternal weight, the treatment of women with GDM diagnosed by IADPSG criteria decreased the risk of LGA and macrosomia, which are closely associated with hyperglycemia. The risks of neonatal intubation and an Apgar score <7 at 5 minutes were also increased in women diagnosed with GDM by the IADPSG cut-off values and in the treatment group. Unlike fetal growth, these immediate neonatal outcomes might be more associated with other intrapartum or obstetric factors other than hyperglycemia. Another analysis concluded that the 1-step IADPSG proposal for GDM was beneficial only if pregnant women were counseled after child birth and received treatment to prevent long-term diabetes [20]. Although the IADPSG recommended integrating screening and diagnosis for GDM in 2011, there is still debate on treatment benefits and there is a lack of consensus on establishing a uniform method for diagnosing GDM.

The glucose values for GDM diagnosis proposed by the IADPSG were chosen by a cut-off where the OR for adverse outcomes (macrosomia, cesarean section, or a raised cord blood C-peptide) was ≥1.75 and 1 abnormal glucose level was used for diagnosis [4]. The new proposal raised the frequency of GDM up to 3-fold in the HAPO cohort. We also found the rate of GDM increased 3-fold when we applied 1 abnormality with IADPSG cut-off values. However, the frequency of GDM diagnosed by IADPSG criteria was 7.5%, much lower than in other reports (18.9–35.5%), because we used the 2-step and not the 1-step approach [171819]. In our study, the frequency of GDM by C-C criteria with a 2-step, 75 g 2-hour OGTT was 2.6%. When a 2-step, 100 g, 3-hour OGTT was applied, the frequency of GDM reported by Korean studies was 1.9–4.0% by the NDDG criteria and 3.6–5.7% by the C-C criteria, respectively [2122]. The racial difference and lower BMI of Korean women may result in a lower incidence of GDM than that reported in other countries.

This study has several limitations with respect to the generalization of the results and the adoption of the new IADPSG criteria. We did not evaluate the cost-effectiveness of the new IADPSG criteria. However, in this study, it was remarkable that most women diagnosed with GDM (92.1%) by 1 or more abnormal values of the IADPSG cut-off values succeeded in controlling glucose through nutritional education and exercise only. In contrast, one third of the women diagnosed with GDM by 2 abnormal values of the C-C cut-off values needed insulin therapy for glucose control. Although we used a 5-year study period, this study was conducted in a single institution, so the number of pregnant women with gestational diabetes was relatively small. The small sample size may affect the lack of difference in shoulder dystocia and birth tract injury associated with fetal overgrowth. Despite these limitations, this is the first study in Korea to prospectively assess the impact of the new IADPSG criteria on perinatal outcomes between treated and not-treated women.

In conclusion, women with GDM diagnosed solely by the IADPSG criteria, and not C-C criteria, also had an increased risk of LGA and macrosomia compared with the control group. However, the risk of excessive fetal growth was reduced if they were treated. This study suggests that the new IADPSG criteria identifies high risk groups for fetal overgrowth, and treatment based on the new criteria may be effective in reducing it.

Acknowledgements

This work received research funding from the Korea Centers for Disease Control and Prevention (2013-E63009-00, 2015-ER-6302-00, 2016-ER6306-00, and 2016-ER6306-01).

Notes

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Ethical approval: The Institutional Review Board of Cheil General Hospital (CGH-IRB-2013-10) approved the contents and research protocol.

Patient consent: This study was performed with informed patient consent.

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Article information Continued

Funded by : Korea Centers for Disease Control & Preventionhttps://doi.org/10.13039/501100003669
Award ID : 2013-E63009-00
Award ID : 2015-ER-6302-00
Award ID : 2016-ER6306-00
Award ID : 2016-ER6306-01

Fig. 1

Enrollment of study population.

GCT, glucose challenge test; C-C, Carpenter-Coustan; IADPSG, International Association of Diabetes and Pregnancy Study Group; GDM, gestational diabetes mellitus.

Table 1

Maternal characteristics of the study population

Characteristics Negative 50g GCT (n=1,979) Positive 50g GCT no-GDM (n=498) GDM by IADPSG non-treatment (n=52) GDM by IADPSG treatment (n=79) GDM by C-C treatment (n=70) P-value
Age (yr) 33.1±3.7 34.1±3.8a) 34.3±3.5 34.6±3.9a) 35.5±3.4a) <0.001
BMI pre-pregnancy (kg/m2) 20.6±2.8 20.7±2.8 22.1±3.6a,b) 22.9±3.7a,b) 23.4±3.7a,b) <0.001
Multiparity 770 (38.9) 215 (43.2) 30 (57.6) 37 (46.8) 37 (52.8) 0.004
Smoking at pre-pregnancy 205 (10.3) 63 (12.6) 9 (17.3) 11 (13.9) 12 (17.1) 0.112
Alcohol at pre-pregnancy 1,655 (83.6) 408 (81.9) 40 (76.9) 70 (88.6) 53 (75.7) 0.151
Family history of DM 519 (26.2) 147 (29.5) 13 (25.0) 33 (41.7) 33 (47.1) <0.001
Total GWG (kg) 13.5±4.4 13.1±4.0 12.4±4.6 10.2±5.4 a,b) 10.2±5.7a,b) <0.001
Insulin therapy - - - 6 (7.9) 23 (32.8) -

BMI, body mass index; C-C, Carpenter-Coustan; DM, diabetes mellitus; GCT, glucose challenge test; GDM, gestational diabetes mellitus; GWG, gestational weight gain; IADPSG, International Association of Diabetes and Pregnancy Study Group; OGTT, oral glucose tolerance test.

a)P<0.05 compared with negative 50 g GCT; b)P<0.05 compared with positive 50 g GCT but no-GDM.

Table 2

Pregnancy outcomes of 5 groups classified by the results of screening and diagnosis of gestational diabetes mellitus (GDM) by different criteria and treatment

Characteristics Negative 50 g GCT (n=1,979) Positive 50 g GCT no-GDM (n=498) GDM by IADPSG non-treatment (n=52) GDM by IADPSG treatment (n=79) GDM by C-C treatment (n=70) P-value
Delivery weeks 38.9±1.4 38.8±1.5 38.8±2.2 38.6±1.6 38.6±1.1 0.033
Neonatal birthweight (g) 3,242±427 3,257±436 3,461±532a,b) 3,299±456 3,331±461 0.003
Male sex of neonate 994 (50.2) 265 (53.2) 30 (57.6) 38 (48.1) 40 (57.1) 0.448
Cesarean delivery 758 (38.3) 216 (43.3) 17 (32.6) 37 (44.8) 37 (52.8) 0.016
Indication of cesarean delivery 0.084
Repeat 241 (31.8) 60 (27.7) 8 (47.1) 16 (43.2) 15 (40.5)
FTP 259 (34.2) 78 (36.1) 3 (17.6) 8 (21.6) 9 (24.3)
NRFS 58 (7.6) 11 (5.1) 3 (17.6) 2 (5.4) 0
Maternal request 54 (7.1) 22 (10.2) 1 (5.9) 6 (1.6) 5 (13.6)
Malpresentation 69 (9.1) 18 (8.3) 1 (5.9) 3 (8.1) 4 (10.8)
Myomectomy 44 (2.2) 18 (8.3) 1 (5.9) 2 (5.4) 1 (2.7)
Others 33 (1.7) 9 (4.2) 0 0 3 (8.1)
LGA 182 (9.2) 51 (10.2) 14 (27.0) 10 (12.6) 13 (18.6) <0.001
Macrosomia 64 (3.2) 11 (2.2) 5 (9.6) 6 (7.5) 7 (10.0) 0.001
SGA 209 (10.5) 56 (11.2) 1 (1.9) 5 (6.3) 5 (7.1) 0.279
Preterm delivery 88 (4.4) 24 (4.8) 6 (11.5) 5 (6.3) 4 (5.7) 0.176
Shoulder dystocia 0 0 0 0 0 -
Birth tract injury 78 (3.9) 28 (5.6) 1 (1.9) 2 (2.5) 3 (4.3) 0.395
Apgar score <7 at 1 min 52 (2.6) 17 (3.4) 2 (3.8) 4 (5.0) 0 0.329
Apgar score <7 at 5 min 9 (0.4) 4 (0.8) 0 2 (2.5) 0 0.129
Admission to NICU 226 (11.4) 60 (12.0) 5 (9.6) 15 (18.9) 4 (5.7) 0.139
Neonatal intubation 87 (4.4) 27 (5.4) 3 (5.7) 8 (10.1) 3 (4.2) 0.185
Phototherapy 545 (27.5) 139 (27.9) 16 (30.7) 26 (32.9) 25 (35.7) 0.491

C-C, Carpenter-Coustan; FTP, failure to progress; GCT, glucose challenge test; IADPSG, International Association of Diabetes and Pregnancy Study Group; LGA, large for gestational age; NICU, neonatal intensive care unit; NRFS, nonreassuring fetal status; SGA, small for gestational age.

a)P<0.05 compared with negative 50 g GCT; b)P<0.05 compared with positive 50 g GCT but no-GDM.

Table 3

Multivariate logistic regression analysis for the association of gestational diabetes mellitus (GDM) treatment by different criteria and risk of pregnancy outcomes

Characteristics Negative 50 g GCT Positive 50 g GCT no-GDM GDM by IADPSG non-treatment GDM by IADPSG treatment GDM by C-C treatment
Cesarean delivery 1.0 (referent) 1.16 (0.95–1.43) 0.67 (0.37–1.22) 1.08 (0.68–1.73) 1.26 (0.76–2.08)
LGA 1.0 (referent) 1.09 (0.78–1.52) 2.81 (1.47–5.38) 1.01 (0.50–2.05) 1.54 (0.80–2.96)
Macrosomia 1.0 (referent) 0.66 (0.34–1.27) 2.84 (1.08–7.47) 2.01 (0.82–4.90) 2.61 (1.11–6.14)
SGA 1.0 (referent) 1.06 (0.77–1.46) 0.21 (0.03–1.52) 0.60 (0.24–1.52) 0.70 (0.27–1.82)
Preterm delivery 1.0 (referent) 1.03 (0.65–1.64) 2.67 (1.10–6.48) 1.30 (0.50–3.35) 1.11 (0.40–3.19)
Apgar score <7 at 1 min 1.0 (referent) 1.29 (0.73–2.26) - 2.30 (0.79–6.71) -
Apgar score <7 at 5 min 1.0 (referent) 1.81 (0.55–5.96) 0.79 (0.31–2.01) 5.88 (1.18–29.36) -
Admission to NICU 1.0 (referent) 1.04 (0.77–1.42) 0.79 (0.31–2.01) 1.61 (0.90–2.91) 0.40 (0.14–1.13)
Neonatal intubation 1.0 (referent) 1.22 (0.78–1.91) 1.33 (0.40–4.37) 2.23 (1.03–4.87) 0.86 (0.26–2.83)
Phototherapy 1.0 (referent) 0.97 (0.78–1.22) 1.17 (0.64–2.14) 1.15 (0.70–1.88) 1.25 (0.75–2.10)

Data are expressed as odds ratios (95% confidence internal) using negative 50 g GCT as reference and are adjusted for maternal age, parity, and body mass index before pregnancy.

C-C, Carpenter-Coustan; GCT, glucose challenge test; IADPSG, International Association of Diabetes and Pregnancy Study Group; LGA, large for gestational age; NICU, neonatal intensive care unit; SGA, small for gestational age.