Korean J Obstet Gynecol Search

CLOSE


Obstet Gynecol Sci > Volume 54(2); 2011 > Article
Korean Journal of Obstetrics & Gynecology 2011;54(2):79-85.
DOI: https://doi.org/10.5468/KJOG.2011.54.2.79    Published online February 1, 2011.
The relationship between amniotic fluid white blood cell count and inflammatory lesions of the placenta in women with preterm premature rupture of membranes.
Eun Ha Jeong, Kyo Hoon Park, Kyung Joon Oh, Sung Youn Lee, Shi Nae Kim, Hee Jung Jung, Jeong Yeun Lee
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. pkh0419@snubh.org
Abstract
OBJECTIVE
To examine the relationship between amniotic fluid (AF) white blood cell (WBC) count and the presence and severity of inflammatory lesions of the placenta in women with preterm premature rupture of membranes (PPROM). METHODS: This retrospective cohort study included 90 consecutive women with PPROM (24.0-35.6 weeks) who met the following criteria: singleton gestation; transabdominal amniocentesis performed to obtain AF for culture and WBC count; delivery within 72 hours of amniocentesis; placental histologic examination after preterm delivery. RESULTS: The prevalence of histologic chorioamnionitis was 32% (29/90) and that of positive amniotic fluid culture was 21% (19/90). Patients with histologic chorioamnionitis had a significantly higher AF WBC count than those without this lesion. Logistic regression analysis demonstrated that AF WBC count had a significant relationship with histologic chorioamnionitis after controlling for gestational age and AF culture. The median AF WBC count increased significantly according to the higher severity of inflammation in each type of placental histologic section. According to receiver operating characteristic curve analysis, the best cut-off value of AF WBC count for predicting histological chorioamnionitis was 25 cells/mm3, with a sensitivity of 62% and a specificity of 77%. CONCLUSION: Both the presence and greater severity of inflammatory lesions of the placenta are associated with an elevated AF WBC count. AF WBC count is an important and independent predictor for inflammatory lesions of the placenta in women with PPROM.
Key Words: Amniotic fluid, White blood cell, Placenta, Inflammatory lesions, Preterm premature rupture of membranes


ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
POLICY
FOR CONTRIBUTORS
Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea
Tel: +82-2-3445-2382    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2021 by Korean Society of Obstetrics and Gynecology.

Developed in M2PI

Close layer
prev next