Is the expression of p16INK4A and galectin-3 correlated with disease progression of cervical neoplasia?.

Kim, Sun suk; Cho, Hye yon; Kang, Sung won; Kim, Hong bae; Park, Sung ho

doi:2011.54.4.192

Obstet Gynecol Sci > Volume 54(4); 2011 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 2011;54(4):192-198.
DOI: https://doi.org/10.5468/KJOG.2011.54.4.192 Published online April 1, 2011.

Is the expression of p16INK4A and galectin-3 correlated with disease progression of cervical neoplasia?.

Sun suk Kim, Hye yon Cho, Sung won Kang, Hong bae Kim, Sung ho Park

Department of Obstetrics and Gynecology, Hallym University College of Medicine, Seoul, Korea. vth2000@naver.com

Abstract

OBJECTIVE
The aim of this study is to investigate whether the expressions of p16INK4A and galectin-3 are associated with the progression of cervical neoplasia and to evaluate its usefulness as a diagnostic tool. METHODS: Eighty-seven formalin-fixed paraffin-embedded cervical specimens (20 normal, 17 LSILs, 26 HSILs, 24 invasive cervical cancers) collected between 2005 and 2009 were selected. We examined the expression of p16INK4A and galectin-3 using immunohistochemical stains with the scoring system. RESULTS: The mean proportion of p16INK4A and galectin-3 was 0.1 and 1.70 in normal lesions, 1.35 and 2.17 in LSILs, 3.42 and 3.11 in HSILs, 3.79 and 3.08 in invasive cancers. The mean proportion of p16INK4A and galectin-3 was correlated significantly with the degree of neoplasia (P<0.05). CONCLUSION: The increased immunohistochemical staining expressions of the p16INK4A and galectin-3 are associated with the progression of cervical neoplasia. Therefore immunohistochemical staining of p16INK4A and galectin-3 can be a useful biomarker for the diagnosis of a progression of cervical neoplasia.

Key Words: p16INK4A, Galectin-3, Uterine Cervical neoplasms, Immunohistochemistry