Is the expression of p16INK4A and galectin-3 correlated with disease progression of cervical neoplasia?. |
Sun suk Kim, Hye yon Cho, Sung won Kang, Hong bae Kim, Sung ho Park |
Department of Obstetrics and Gynecology, Hallym University College of Medicine, Seoul, Korea. vth2000@naver.com |
|
Abstract |
OBJECTIVE The aim of this study is to investigate whether the expressions of p16INK4A and galectin-3 are associated with the progression of cervical neoplasia and to evaluate its usefulness as a diagnostic tool. METHODS: Eighty-seven formalin-fixed paraffin-embedded cervical specimens (20 normal, 17 LSILs, 26 HSILs, 24 invasive cervical cancers) collected between 2005 and 2009 were selected. We examined the expression of p16INK4A and galectin-3 using immunohistochemical stains with the scoring system. RESULTS: The mean proportion of p16INK4A and galectin-3 was 0.1 and 1.70 in normal lesions, 1.35 and 2.17 in LSILs, 3.42 and 3.11 in HSILs, 3.79 and 3.08 in invasive cancers. The mean proportion of p16INK4A and galectin-3 was correlated significantly with the degree of neoplasia (P<0.05). CONCLUSION: The increased immunohistochemical staining expressions of the p16INK4A and galectin-3 are associated with the progression of cervical neoplasia. Therefore immunohistochemical staining of p16INK4A and galectin-3 can be a useful biomarker for the diagnosis of a progression of cervical neoplasia. |
Key Words:
p16INK4A, Galectin-3, Uterine Cervical neoplasms, Immunohistochemistry |
|