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Obstet Gynecol Sci > Volume 54(5); 2011 > Article
Korean Journal of Obstetrics & Gynecology 2011;54(5):229-235.
DOI: https://doi.org/10.5468/KJOG.2011.54.5.229    Published online May 1, 2011.
Clinical usefulness of soluble fms-like tyrosine kinase 1, soluble endoglin and placental growth factor in Korean women with preeclampsia.
Ham Bak Lee, Ki Cheol Kil, Sun Young Nam, Jae Eun Shin, Ju Young Cheon, Young Lee
Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, Seoul, Korea. ly@catholic.ac.kr
Abstract
OBJECTIVE
To evaluate the clinical significance of soluble fms-like tyrosine kinase1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PlGF) in preeclampsia. METHODS: We conducted a case-control study analyzing serum levels of sFlt-1, sEng and PlGF in women with preeclampsia (n=30) and normal pregnancy (n=30) in the third trimester. We calculated the sensitivity, specificity, positive, and negative predictive values of each peptide in diagnosing preeclampsia. RESULTS: The mean serum level of sFlt-1 and sEng in women with preeclampsia was significantly higher than normal pregnancy. But the mean serum level of PIGF had no significant difference between two groups. The cut-off values of sFlt-1 and sEng showing differential significance were 26.3 ng/mL and 21.1 ng/mL each. Then the sensitivity, specificity, positive predictive value, negative predictive value was all over 80%. Serum levels of sFlt-1 and sEng were not significantly different between intrauterine growth restriction (IUGR) and non-IUGR group among preeclamptic women. CONCLUSION: Serum levels of both sFlt-1 and sEng may be useful in diagnosing patients with preeclampsia. The serum levels of these factors may not correlate with poor perinatal outcomes.
Key Words: Preeclampsia, Soluble fms-like tyrosine kinase 1, Soluble endoglin, Placental growth factor, Intrauterine growth restriction


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