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Obstet Gynecol Sci > Volume 54(6); 2011 > Article
Korean Journal of Obstetrics & Gynecology 2011;54(6):294-299.
DOI: https://doi.org/10.5468/KJOG.2011.54.6.294    Published online June 1, 2011.
Histologic comparison of polycystic ovary syndrome induced by estradiol valerate and letrozole.
Sung Chul Lim, Moon Jin Jeong, Se Eun Kim, Seung Hyun Kim, Sam Cheol Kim, Seung Yong Seo, Tak Kim, Seong Soo Kang, Chun Sik Bae
1Department of Pathology, Chosun University College of Medicine, Gwangju, Korea.
2Department of Oral Histology, Chosun University College of Dentistry, Gwangju, Korea.
3Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine, Gwangju, Korea. csbae210@chonnam.ac.kr
4Department of Medicine, Graduate School Chosun University, Gwangju, Korea.
5Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
To compare ovarian morphology of the estradiol valerate (EV)- and the letrozole (LE)-induced polycystic ovary syndrome (PCOS) in rat models. METHODS: EV were injected (IM) to 10 Sprague-Dawley rats and LE were administered (PO) to the other 10 Sprague-Dawley rats for 21 days. Sixty days after single injection of EV and 21 days after LE administration, the animals were sacrificed and the ovaries were sectioned, measured and analyzed histopathologically. RESULTS: LE-treated group showed larger ovary bearing more abundant cystic follicles with luteinized theca cells. These findings were more similar to human PCOS ovarian morphology. CONCLUSION: LE-induced PCOS model is recommended to conduct PCOS-related animal experiments.
Key Words: Polycystic ovary syndrome, Estradiol valerate, Letrozole, Ovary
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