The Correlation of cervical intraepithelial neoplasia 3 detected by cervical punch biopsies with the pathologic results of conization and hysterectomy. |
Ki Won Kim, Kyoung Mi Kim, Jung Woo Park, Hyun Jae Jung, Jee Young Han, Joon Mee Kim, Jee Hyun Park, Sung Ook Hwang, Woo Young Lee, Eunseop Song |
1Department of Obstetrics and Gynecology, Inha University College of Medicine, Incheon, Korea. songsong2000@hotmail.com 2Department of Pathology, Inha University College of Medicine, Incheon, Korea. |
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Abstract |
OBJECTIVE To know the correlation of punch-biopsy proven cervical intraepithelial neoplasia (CIN) 3 with the results of cone and hysterectomy. METHODS: We reviewed the medical records from 1999 to 2008, retrospectively, at a single institution. We checked age, cone and hysterectomy biopsy results, preoperative cervical smear results as well as human papillomavirus results. RESULTS: There were 104 patients whose punch biopsy results were CIN 3. 59 (56.7%) patients underwent cone and 45 did hysterectomy after punch biopsies. Cone found 6.8% of cervical cancer. Among patients undergoing hysterectomy without cone, 8.9% had cervical cancers. There were a lot of inflammations, atypical squamous cells of unknown significance, low-grade squamous intraepithelial lesion done as a Pap results just before cone. The positive rate of HPV was 80.0%. There were 5.1% of under-estimated and 6.8% of over-estimated results according to the cone results, and 6.7% of under-estimated and 8.9% of over-estimated according to the hysterectomy results. CONCLUSION: Through conization, 93.2% of the patients whose punch biopsy results were CIN 3 had CIN and did not need hysterectomy, and 6.8% had cervical cancers and might need further treatment. Through hysterectomy, 91.2% had CIN and might undergo overtreatment. |
Key Words:
Cervical intraepithelial neoplasia, Uterine cervical cancer, Biopsy, Conization, Hysterectomy |
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