| Concentration of cord serum adiponectin in normal and gestational diabetic pregnancies. |
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Ah Ra Cho, Young Ju Kim, Sun Hee Chun, Su Jin Cho, Eun Ae Park, Mi Hye Park |
1Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea. ewhapmh@ewha.ac.kr
2Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea. |
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| Abstract |
OBJECTIVE
To investigate the effect of intrauterine environment on adiponectin level in cord blood through comparison of normal pregnancy group and gestational diabetes group. METHODS: This cross sectional study included women with: normal pregnancy (n = 204); and patients with gestational diabetes mellitus (GDM) (n = 204). Among GDM patients, 118 were managed with diet alone and 86 were insulin requiring. Cord serum adiponectin concentration at birth was measured by enzyme-linked immunosorbent assay. RESULTS: Cord serum adiponectin concentration was higher in GDM treatment pregnancies compared with normal pregnancies (P = 0.02). Cord serum adiponectin concentration was higher in female compared with male fetuses both normal and gestational diabetes pregnancies (P = 0.04, P = 0.03). In normal pregnancies, cord serum adiponectin concentration was positively correlated with gestational age (r = 0.2374, P < 0.02). In normal pregnancies, cord serum adiponectin concentration did not correlated with birth weight (r = -0.05, P > 0.05). Cord serum adiponectin concentration was not different between only diet treated women and insulin requiring women in GDM (P > 0.05). CONCLUSION: Sex dimorphism for adiponectin and the change of adiponectin in GDM offsprings, first appear in utero. Higher adiponectin levels in females or GDM offsprings reflect increased adiposity of the fetuses. |
| Key Words:
Cord serum adiponectin, Gestational diabetes mellitus, Sex characteristics, Adiposity |
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