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Obstet Gynecol Sci > Volume 54(10); 2011 > Article
Korean Journal of Obstetrics & Gynecology 2011;54(10):599-604.
DOI: https://doi.org/10.5468/KJOG.2011.54.10.599    Published online October 1, 2011.
Oral contraceptive pill pretreatment in ovarian stimulation with GnRH antagonists for in vitro fertilization: A comparative study.
Youn Sil Choo, Ae Ra Han, Seung Heon Yang, Na Young Sung, Sun Hwa Cha, Hye Ok Kim, Chan Woo Park, In Ok Song, Mi Kyoung Koong, In Soo Kang, Kwang Moon Yang
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. kmlyang@naver.com
To evaluate whether oral contraceptive pill (OCP) pretreatments in gonadotropin-releasing hormone (GnRH) antagonist ovarian stimulation protocols takes positive effects on in vitro fertilization (IVF) outcomes in respect to retrieved oocyte number, oocyte maturation rate, fertilization rate, good quality embryo rate, cycle cancellation rate, pregnancy rate and clinical abortion rate. METHODS: A total of 194 cycles using GnRH antagonist protocol was performed at infertility clinic of our institute from September 1st, 2009 to February 28th, 2010. The medical records of GnRH antagonist protocols for IVF with or without OCP pretreatment in our IVF unit were retrospectively analyzed. We compared the IVF outcomes between OCP pretreated (n=41) and no pretreatment group (n=153). RESULTS: In cycles with OCP pretreated group, the total used dosage of gonadotropin (3019.38+/-1379.00 IU) were higher than that of no pretreatment group (2551.52 +/- 1157.05 IU, P = 0.054). The duration of ovarian stimulation in OCP pretreated group (11.5 +/- 2.0) was significantly longer than that of control group (9.5 +/- 1.9, P = 0.000). The number of gained total embryo (2.8+/-0.9 vs. 2.5+/-1.0, P = 0.055) and fertilization rate (77.2% vs. 65.5%, P = 0.017) were significantly higher in OCP pretreated group. There is no significant difference in pregnancy rate between two groups (39.4% vs. 30.0%, P = 0.304). CONCLUSION: OCP pretreatment before GnRH antagonist protocol for IVF appears not to have reliable benefit in terms of IVF outcomes. Well-controlled and large-scaled studies are needed.
Key Words: Gonadotropin-releasing hormone antagonist, Oral contraceptive pill pretreatment, Ovarian stimulation, In vitro fertilization

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