A case of atypical hemolytic uremic syndrome in a patient with preeclampsia.

Jeon, Hye Ji; Hyun, Hye Sun; Lee, Mi Ra; Choi, Sl A; Kim, Yun Sook; Bae, Dong Han; Kim, Hui Jun

doi:2011.54.10.626

Obstet Gynecol Sci > Volume 54(10); 2011 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2011;54(10):626-629.
DOI: https://doi.org/10.5468/KJOG.2011.54.10.626 Published online October 1, 2011.

A case of atypical hemolytic uremic syndrome in a patient with preeclampsia.

Hye Ji Jeon, Hye Sun Hyun, Mi Ra Lee, Sl A Choi, Yun Sook Kim, Dong Han Bae, Hui Jun Kim

¹Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea. drsook@schmc.ac.kr
²Department of Laboratory Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

Abstract

Atypical hemolytic uremic syndrome (HUS) in adults is a life-threatening disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure, which is not related to Escherichia coli. This disease occurs under the condition of certain stresses, including pregnancy related disease like as preeclampsia, placental abruption, and amniotic fluid embolism. Heparin and plasma exchange has proven to be an effective treatment for HUS and it has decreased the mortality of this illness. We experienced a case of 34 weeks' pregnant woman with preeclampsia who presented with hematuria, oliguria, hemolytic anemia and thrombocytopenia. We performed emergency cesarean section due to fetal distress. After operation, she was treated with transfusion of packed red blood cell, parenteral albumin, and anticoagulant. After seven days from the operation, the sign of hematuria disappeared and her renal function partially recovered. We describe this case with a brief review of the literature.

Key Words: Atypical hemolytic uremic syndrome, Pre-eclampsia, Pregnancy