A case of squamous cell carcinoma of the uterine cervix with diffuse hematogenous lung metastasis in a 36-year-old virgin.

Shim, A Ra; Choi, Eun Kyoung; Yun, Sung Hyun; Lee, Maria; Lee, Mi Kyung; Kim, Sang Wun

doi:2011.54.10.634

Case Report

Korean Journal of Obstetrics & Gynecology 2011;54(10):634-638.
DOI: https://doi.org/10.5468/KJOG.2011.54.10.634 Published online October 1, 2011.

A case of squamous cell carcinoma of the uterine cervix with diffuse hematogenous lung metastasis in a 36-year-old virgin.

A Ra Shim, Eun Kyoung Choi, Sung Hyun Yun, Maria Lee, Mi Kyung Lee, Sang Wun Kim

¹Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. san1@yuhs.ac
²Department of Obstetrics and Gynecology, The National Health Insurance Corporation Ilsan Hospital, Koyang, Korea.
³Department of Diagnostic Pathology, The National Health Insurance Corporation Ilsan Hospital, Koyang, Korea.

Abstract

The carcinoma of the uterine cervix in virgins is extremely rare. A 36-year-old virgin presented with a 4.8 x 2.2 cm sized endocervical mass with bleeding on sonography. Biopsy revealed a squamous cell carcinoma arising in the uterine cervix without human papilloma virus (HPV) DNA. Positron emission tomography revealed cervical cancer with multiple hematogenous lung metastases. After 3 cycles of preoperative chemotherapy, she underwent modified radical hysterectomy and 6 cycles of postoperative chemotherapy. After the treatment, complete resolution was obtained, and she has been followed without recurrence for 4 years. Although > 90% of cervical cancer is caused by HPV infection, we cannot completely deny the possibility of HPV negative cervical carcinoma.

Key Words: Squamous cell carcinoma, Virgin, Human papilloma virus DNA negative