![]() |
![]() |
Obstet Gynecol Sci > Volume 66(5); 2023 > Article |
|
Study | Design | Participants | Intervention | Comparison | Outcomes and follow up duration | Hypothesis/objectives |
---|---|---|---|---|---|---|
Cooper et al. [15] (2019) | Randomized multicenter control yrial in the UK |
664 women referred to gynecologist for surgical treatment of HMB Inclusion criteria: |
Second generation endometrial ablation (333) | Laparoscopic supracervical hysterectomy (331) |
Primary outcomes:
|
To compare patient satisfaction & condition-specific quality of life in women receiving hysterectomy versus endometrial ablation |
Elmantwe et al. [25] (2017) | Randomized single-centered control trial in Benha, Egypt |
40 women diagnosed with HMB, refractory to medical treatment Inclusion criteria: |
Bipolar endometrial resection (n=20) | Non descent vaginal hysterectomy (n=20) |
Primary outcomes:
|
To identify the number of women with HMB, 6 months after bipolar endometrial resection |
Jain et al. [17] (2016) | Randomized single centered control trial in Delhi, India |
40 women diagnosed with HMB Inclusion criteria: |
Thermal balloon ablation (n=20) | Vaginal hysterectomy (n=20) |
Primary outcomes:
|
To identify the number of women with HMB, 6 months after thermal balloon ablation |
Zupi et al. [24] (2015) | Randomized single centered control trial in Rome, Catanzaro and Naples, Italy |
181 women affected by menometrorrhagia and unresponsive to medical treatment Inclusion criteria: |
Hysteroscopic endometrial resection (n=89) | Laparoscopic supracervical hysterectomy (n=92) | Primary outcomes: Secondary outcomes: | To compare the relative efficacy and safety of hysteroscopic endometrial resection and laparoscopic supracervical hysterectomy in the treatment of abnormal uterine bleeding |
Sesti et al. [19] (2011) | Randomized single centered control trial, Rome, Italy |
68 women requiring surgical therapy for HMB Inclusion criteria: |
Thermal balloon ablation (n=34) | Laparoscopic supracervical hysterectomy (n=34) | Primary outcomes: Secondary outcomes: | To compare the effects of thermal balloon ablation versus laparoscopic supracervical hysterectomy on menstrual bleeding |
Dickersin et al. [16] (2007) | Randomized multicenter control trial, USA |
237 women Inclusions criteria: 51 lost at 2-year FU |
Endometrial ablation resectoscopic endometrial ablation with electrodesiccation/coagulation or vaporisation OR ablation with thermal balloon (n=123) | Vaginal, laparoscopic or abdominal hysterectomy (n=114) |
Primary outcomes:
|
To compare the effectiveness of hysterectomy and endometrial ablation in women with dysfunctional uterine bleeding |
Lin et al. [18] (2006) | Single centre quasi-randomised trial, China |
60 women with HMB, for whom conservative treatment was proven ineffective. Mild to moderate anaemia (level of haemoglobin ranged from 60 g/L to 100 g/L with an average of 83 g/L) Inclusion criteria: |
Microwave endometrial ablation (n=30) | Total transabdominal hysterectomy (n=30) | All patients were followed up for 6 to 20 months after operation | Comparison between microwave endometrial ablation and total hysterectomy |
Crosignani et al. [20] (1997) | Single centre RCT, Milan, Italy |
95 women Inclusion criteria:
|
Hysteroscopic endometrial resection (n=41) | Vaginal hysterectomy (n=44) | Primary outcomes: Secondary outcomes: | To compare patients’ satisfaction with the effect of treatment, health related quality of life, psychologic status, and sexual functioning 2 years after endometrial resection or vaginal hysterectomy for menorrhagia |
O’Connor et al. [22] (1997) | Multicentre RCT, London, UK |
202 women Inclusion criteria:
|
Transcervical endometrial resection (n=116) |
Hysterectomy (n=56) Abdominal (n=28), vaginal (n=28) |
Primary outcomes:
Secondary outcomes:
|
Comparison of endometrial resection versus hysterectomy in management of menorrhagia |
Dwyer et al. [23] (1993) (Sculpher et al. [42] [1996]) |
Single centre RCT, Middlesex, UK |
200 women Inclusion criteria: |
Transcervical endometrial resection (n=100) | Abdominal hysterectomy (n=100) | Primary outcomes: | To compare the impact of endometrial resection and abdominal hysterectomy on a range of health outcomes and health service costs, based on longer term follow up of patients randomised to a clinical trial |
Pinion et al. [26] (1994) (Alexander et al. [45] [1996]; Cameron et al. [44] [1996]; Aberdeen Endometrial Ablation Trials Group [43] [1999]) |
Single centre RCT, Aberdeen, UK |
204 women Inclusion criteria: |
Endometrial laser ablation (n=53) Transcervical resection of the endometrium (n=52) |
Hysterectomy (n=99) (n=87 abdominal hysterectomies, n=12 vaginal hysterectomies) |
Primary outcomes: Secondary outcomes: | To evaluate the effectiveness and safety of endometrial laser ablation and transcervical resection of the endometrium compared with hysterectomy in the surgical treatment of women with dysfunctional uterine bleeding |
Gannon et al. [21] (1991) | Single centre RCT, Reading, UK |
51 women Inclusion criteria: |
Endometrial resection (n=25) | Abdominal hysterectomy (n=26) | Primary outcomes: Secondary outcomes: | To determine the advantages and dis-advantages of endometrial resection and abdominal hysterectomy for the surgical treatment of women with menorrhagia |
UK, United Kingdom; HMB, heavy menstrual bleeding; FU, follow up; MMAS, menorrhagia multi-attribute quality of life score; SF-12, standard form 12; EuroQOL, European quality of life; PBAC, pictorial blood loos assessment chart; UFS-QOL, uterine fibroid symptom and quality of life; VAS, visual analogue scale; PAP, papanicolaou; USS, ultrasound scan; OR, odds ratio; RCT, randomized control trial; HADS, hospital anxiety and depression; SSRS, sabbatsberg sexual rating scale; PMS, premenstrual syndrome.
![]() |
![]() |