A case of complete androgen insensitivity syndrome with malignant mixed germ cell tumors.

Lee, Kyung Hee; Lim, You Jin; Lee, Jong Shim; Kim, Mi Sung; Jo, Jeong Hyeon; Kim, Kyu Rae; Park, Jeong Yeol; Kim, Jong Hyeok

doi:2011.54.11.701

Obstet Gynecol Sci > Volume 54(11); 2011 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2011;54(11):701-706.
DOI: https://doi.org/10.5468/KJOG.2011.54.11.701 Published online November 1, 2011.

A case of complete androgen insensitivity syndrome with malignant mixed germ cell tumors.

Kyung Hee Lee, You Jin Lim, Jong Shim Lee, Mi Sung Kim, Jeong Hyeon Jo, Kyu Rae Kim, Jeong Yeol Park, Jong Hyeok Kim

¹Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hyeokkim@amc.seoul.kr
²Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Abstract

Androgen insensitivity syndrome cases have an increased risk of developing testicular cancer due to many factors such as mutations, hormonal disturbances involving gonadotropins and cryptorchidism. However, malignant germ cell tumor is relatively rarely found compared to those seen in other types of intersex. Recently, the authors experienced a case of malignant mixed germ cell tumor with lymph node metastasis and chemotherapy resistance which was developed in a 31-year-old patient with complete androgen insensitivity syndrome.

Key Words: Androgen insensitivity syndrome, Malignant mixed germ cell tumor