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Obstet Gynecol Sci > Volume 65(3); 2022 > Article
Sookaromdee and Wiwanitkit: Contraception, vaccination and coronavirus disease 2019 pandemic: correspondence
Dear Editor, we would like to discuss the publication entitled “Contraception in the coronavirus disease 2019 (COVID-19) pandemic: recommendations from the Korean society of contraception and reproductive health” [1]. Lee et al. [1] mentioned that “rare form of thrombosis has been reported in people who received the COVID-19 vaccine, most of whom were women younger than 50 years of age… of guidelines for the use of hormonal contraceptives in the era of the COVID-19 pandemic is necessary”. We agree that the COVID-19 vaccine can have adverse effects. The question regarding risks related to contraception is an interesting one. We agree that the usefulness and benefit of vaccination are superior to the risk. Regarding thrombosis in a COVID-19 vaccine recipient who uses contraception, there might be some previous reports. However, it should be noted that most studies lack data on the pre-vaccination status of the patient. Patients with a history of contraceptive drug use might have underlying diseases that can lead to thrombosis. It should also be noted that not all thromboses that occur after vaccination are caused by vaccination. The patient might have other medical problems leading to thrombosis [2]. Considering the pathogenesis of thrombosis, an important mechanism is increased blood viscosity [3]. Focusing on contraceptive drug use, increased blood viscosity might be observed [4]. However, the increased level is not high and does not increase the risk of vaccine-related thrombosis. The problem should be a concern only if there is an additional medical illness, such as metabolic syndrome and cardiac problems, in vaccinated women. Therefore, we should reassure the safety of COVID-19 vaccination for any woman with concomitant use of contraceptive drug.


Conflict of interest

No potential conflict of interest relevant to this article was reported.

Ethical approval

This study does not require approval of the Institutional Review Board because no patient data is contained in this article. The study was performed in accordance with the principles of the Declaration of Helsinki.

Patient consent

Written informed consent and the use of images from patients are not required for the publication.

Funding information



1. Lee JH, Song JY, Yi KW, Kim JJ, Hwang KR, Shin JH, et al. Contraception in the COVID-19 pandemic: recommendations from the Korean society of contraception and reproductive health. Obstet Gynecol Sci 2022 Jan 26 [Epub]. https://doi.org/10.5468/ogs.21322.
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2. Mungmunpuntipantip R, Wiwanitkit V. Thrombosis after adenovirus-vectored COVID-19 vaccination: a concern on underlying illness. Clin Appl Thromb Hemost 2021;27:10760296211060446.
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3. Joob B, Wiwanitkit V. Expected viscosity after COVID-19 vaccination, hyperviscosity and previous COVID-19. Clin Appl Thromb Hemost 2021;27:10760296211020833.
crossref pmid pmc pdf
4. Lowe GD, Drummond MM, Forbes CD, Barbenel JC. Increased blood viscosity in young women using oral contraceptives. Am J Obstet Gynecol 1980;137:840-2.
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