A case of unrecognized pregnancy during chemotherapy in non-small cell lung cancer patient.

Park, Jee Yoon; Park, Jeong Woo; Lee, Dong Ock; Park, Chan Wook; Park, Joong Shin; Jun, Jong Kwan; Syn, Hee Chul

doi:2011.54.12.807

Obstet Gynecol Sci > Volume 54(12); 2011 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2011;54(12):807-811.
DOI: https://doi.org/10.5468/KJOG.2011.54.12.807 Published online December 1, 2011.

A case of unrecognized pregnancy during chemotherapy in non-small cell lung cancer patient.

Jee Yoon Park, Jeong Woo Park, Dong Ock Lee, Chan Wook Park, Joong Shin Park, Jong Kwan Jun, Hee Chul Syn

¹Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. jsparkmd@snu.ac.kr
²Center for Uterine Cancer, National Cancer Center, Goyang, Korea.

Abstract

Most chemotherapeutic drugs are known to possess significant teratogenic effects. Although several agents have been proven to be safe for the fetus after organogenesis period, there is limited information on their use during pregnancy and it is very difficult to establish researches on the effect to human. We report a very unique case of unrecognized pregnancy in lung cancer patient who had been treated with variable agents of chemotherapy. A 25-year-old woman (gravida 0) who had been diagnosed as non-small cell lung cancer 6 years ago and received multiple regimens of chemotherapy presented at full term pregnancy with unknown gestational period. Without knowledge of pregnancy, she received a palliative chemotherapy with Docetaxel during first and second trimesters. Vaginal delivery with induction of labor due to postterm pregnancy was performed after evaluation of her medical condition and fetal surveillance. A 2,450 g female newborn was delivered with no evidence of congenital malformations.

Key Words: Pregnancy, Lung neoplasmas, Antineoplastic combined chemotherapy protocols