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Obstet Gynecol Sci > Volume 55(1); 2012 > Article
Korean Journal of Obstetrics & Gynecology 2012;55(1):51-54.
DOI: https://doi.org/10.5468/KJOG.2012.55.1.51    Published online January 1, 2012.
A case of Rathke's cleft cyst presenting with amenorrhea.
Young Sin Park, Mee Hwa Lee, Tae Heon Kim, Hang Yong Jang, Gyong Mi Lee
1Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Korea. yeegen@cha.ac.kr
2Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
A 28-year-old female presented with Rathke's cleft cysts (RCC) manifesting as primary amenorrhea and no development of secondary sexual characteristics. She had no symptoms of headache, visual disturbance, anosmia or galactorrhea.. The endocrinologic study demonstrated partial hypopituitarism. Magnetic resonance imaging revealed about 1.5 cm sized sellar and suprasellar cystic tumor, extending into the pituitary stalk. Its tentative diagnosis was benign pituitary cystic tumor, such as RCC. She underwent surgery by a transsphenoidal approach. Histological examination revealed a ciliated columnar epithelium those consistent with RCC. RCC is rarely symptomatic, but mechanical compression by the cyst or inflammation itself causes headache, visual field defects, or symptoms of pituitary dysfunction. The present case shows that RCC may manifest as hypogonadotropic hypogonadism.
Key Words: Rathke's cleft cysts, Amenorrhea, Hypogonadotropic hypogonadism

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