A case of growing teratoma syndrome in mixed germ cell tumors of the ovary.

Lee, Yeri; You, Ji Yeon; Choi, Chel Hun; Kim, Byung Gie; Bae, Duk Soo; Lee, Je Ho

doi:2012.55.2.123

Case Report

Korean Journal of Obstetrics & Gynecology 2012;55(2):123-126.
DOI: https://doi.org/10.5468/KJOG.2012.55.2.123 Published online February 1, 2012.

A case of growing teratoma syndrome in mixed germ cell tumors of the ovary.

Yeri Lee, Ji Yeon You, Chel Hun Choi, Byung Gie Kim, Duk Soo Bae, Je Ho Lee

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jehojeho.lee@samsung.com

Abstract

Growing teratoma syndrome (GTS) is an increase in tumor size containing only mature teratoma component, during or after chemotherapy for germ cell tumors. A surgical resection is important to confirm diagnosis and is considered as the most appropriate therapeutic management. GTS is rare event in association with ovarian germ cell tumors. In this report, we present a case of GTS which occurred following the treatment of mixed ovarian germ cell tumor with immature teratoma and endodermal sinus tumor. The patient was given adjuvant chemotherapy consisting of six cycles of etoposide and cisplatin. Abdomen pelvis computed tomography performed after chemotherapy demonstrated no evidence of recurrence. She is on regular follow up and remained disease-free for 8 months following second surgery.

Key Words: Growing teratoma syndrome, Mixed germ cell tumor, Ovary