A case of clear cell adenocarcinoma in the uterine cervix of 52-year-old virgin.

Lee, Young Lan; Chang, Kylie Hae Jin; Kyung, Min Sun; Kim, Hong Bae; Park, Sung Ho

doi:2012.55.3.192

Case Report

Korean Journal of Obstetrics & Gynecology 2012;55(3):192-196.
DOI: https://doi.org/10.5468/KJOG.2012.55.3.192 Published online March 1, 2012.

A case of clear cell adenocarcinoma in the uterine cervix of 52-year-old virgin.

Young Lan Lee, Kylie Hae Jin Chang, Min Sun Kyung, Hong Bae Kim, Sung Ho Park

Department of Obstetrics and Gynecology, Hallym University College of Medicine, Seoul, Korea. vth2000@naver.com

Abstract

Clear cell adenocarcinoma (CCAC) of uterine cervix is very rare tumor and only 4%-9% of entire adenocarcinoma appears to be diagnosed as clear cell type. Risk factors and pathogenesis of this disease are not exactly revealed. The intrauterine exposure to diethylstilbestrol (DES) and associated non-steroidal estrogen during pregnancy before 18 weeks is the only known risk factor, and also hormonal changes or genetic causes are suggested as the risk factors. We report a case of CCAC in the uterine cervix of 52-year-old virgin who had never been exposed to DES, with a brief review of related literature.

Key Words: Clear cell adenocarcinoma, Diethylstilbestrol, Virgin