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Obstet Gynecol Sci > Volume 55(5); 2012 > Article
Korean Journal of Obstetrics & Gynecology 2012;55(5):315-324.
DOI: https://doi.org/10.5468/KJOG.2012.55.5.315    Published online May 16, 2012.
Anti-Mullerian hormone in women with polycystic ovary syndrome.
Si Yeon You, So Yun Park, Ga Young Yang, Kyung Ah Jeong, Young Ju Kim, Hye Won Chung
Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea. ogjeong@ewha.ac.kr
Abstract
OBJECTIVE
The aim of this study is to investigate the relationship between anti-Mullerian hormone (AMH) and parameters related to polycystic ovary syndrome (PCOS). METHODS: We measured serum AMH levels in 100 women with PCOS by Rotterdam European Society for Human Reproduction and Embryology criteria. We conducted somatometry, blood test and transvaginal or transrectal ultrasound test. We compared and analyzed AMH and parameters in terms of insulin resistance according to PCOS related phenotypes. We divided phenotypes into four groups by polycystic ovarian morphology (PCOM) and hyperandrogenemia (total testosterone [TT], free testosterone [fT]). RESULTS: AMH levels ranged from 4.1 to 21.0 ng/mL and the mean level was 10.4 +/- 4.1 ng/mL. Significant differences in parameters of insulin resistance were not observed among low (4 to 8 ng/mL), moderate (8 to 12 ng/mL), and high (>12 ng/mL) levels of AMH. Significant differences in AMH were not observed among groups according to PCOS related phenotypes. Weight, body mass index, waist-hip ratio, TT, fT, sex hormone binding globulin, 2-hour insulin and homeostasis model assessment of insulin resistance index were different significantly according to PCOS related phenotypes. TT, ovarian volume and follicle number were positively correlated with AMH. CONCLUSION: Increased serum AMH levels in PCOS are correlated with TT and PCOM.
Key Words: Anti-Mullerian hormone, Polycystic ovary syndrome, Testosterone, Polycystic ovarian morphology


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