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Obstet Gynecol Sci > Volume 55(5); 2012 > Article
Korean Journal of Obstetrics & Gynecology 2012;55(5):343-347.
DOI: https://doi.org/10.5468/KJOG.2012.55.5.343    Published online May 16, 2012.
Primary malignant melanoma of the uterine cervix: A case report.
Nae Ri Yun, Jung Woo Park, Jee Hyun Park, Suk Jin Choi, Sung Ook Hwang
1Department Obstetrics and Gynecology, Inha University College of Medicine, Incheon, Korea. sohwang@inha.ac.kr
2Department Pathology, Inha University College of Medicine, Incheon, Korea.
After the discovery of melanocytes in the cervix in 1959, it was recognized that primary malignant melanoma of the cervix exists as a separate entity. A 74-year-old woman visited hospital for vaginal bleeding from a black colored cervical mass. The pathology of cervical punch biopsy showed a malignant melanoma with positive immnunohistochemical stainings for S100 protein and HMB-45 antibody. Abdominal radical hysterectomy with pelvic and paraaortic lymphadenectomy was performed. The final pathology was a malignant melanoma of the cervix with metastases for both external iliac lymph nodes and tumor involvement in the margin of vaginal resection. She received cisplatin based concurrent chemoradiotherapy postoperatively. But 6 months later, she received another chemotherapy with dacarbazine and cisplatin for recurrence. We report a case of a 74-year-old patient with a malignant melanoma of the uterine cervix with a brief review.
Key Words: Malignant melanoma, Uterine cervix, Vaginal bleeding

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