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Korean Journal of Obstetrics & Gynecology 1997;40(2):275-280.
Published online January 1, 2001.
The Association with Amniotic Fluid Interleukin-6 and Histologic Chorioamnionitis in Patients with Preterm Labor and Intact Membranes.
Young Ju Kim, Mi Hye Park, Jung Ja Ahn, Bock Hi Woo, Wha Soon Chung
1Department of Obstetrics and Gynecology, College of Medicine, Ewha Medical Research Center, Ewha Womans University, Korea.
2Department of Clinical Pathology,College of Medicine, Ewha Medical Research Center, Ewha Womans University, Korea.
Our purpose was to determine whether amniotic amniotic fluid concentrations of interleukin-6 are valuable in the prediction of histologic chorioamnionitis and in the prediction of perinatal morbidity. STUDY DESIGN: The relation among amniotic fluid imterleukin-6, histologic chorioamnionitis, and perinatal outcome was examined in patients with preterm labor and intact membranes. Interleukin-6 was determined by ELISA method. RESULTS: Patients with histologic chorioamnionitis had significantly higher amniotic fluld interleukin-6 concentrations than patient without histologic chrioamnionitis. Also, patient with histologic chorioamnioitis had significantly higher perinatal morbidity rate than patient without histologic chorioamnionitis. An ammiotic fluld interlerkin-6 concentration had a sensitivity of 75% and a specificity of 62.5% in the diagnosis of preterm delivery. CONCLUSION: Amniotic fluld interleukin-6 is a sensitive test for the prediction of histologic chorioamnionitis and of perinatal morbidity.
Key Words: Amniotic fluid, Interleukin-6, Perinatal morbidity, Histologic chorioamnionitis

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