Tumor Necrosis Factor-alpha in Midtrimester Amniotic Fluid is Associated with Pregnancy Outcome?.

Choi, Hyung Min; Cho, Jae Sung; Kim, Kyung Soo; Yang, Young Ho; Park, Yong Won; Kim, Jae Wook

Original Article

Korean Journal of Obstetrics & Gynecology 1997;40(2):281-285.
Published online January 1, 2001.

Tumor Necrosis Factor-alpha in Midtrimester Amniotic Fluid is Associated with Pregnancy Outcome?.

Hyung Min Choi, Jae Sung Cho, Kyung Soo Kim, Young Ho Yang, Yong Won Park, Jae Wook Kim

Department of Obstetrics and Gynecology, College of Medicine, Yonsei University, Seoul, Korea.

Abstract

OBJECTIVE
Our purpose is to investigate if tumor necrosis factor-alpha(TNF-alpha) levels in midtrimester correlate with pregnancies complicated by preterm labor, preeclamsia, and intrauterine growth retardation(IUGR). STUDY DESIGN: A case control study design was used to compare midtrimester amniotic fluid TNF-alpha levels from women with normal pregnancy outcome(n=54) and pregnancies complicated by preterm labor(n=10), preeclampsia(n=8), and IUGR(n=4). RESULT: TNF-alpha levels in midtrimester amniotic fluid in women with normal pregnancy ourcome were 8.8+/-4.0pg/ml. Also, TNF-alpha levels in women with preterm labor, preeclamsia, and IUGR were 9.7+/-6.0pg/ml, 6.0+/-4.1pg/ml, 7.5+/-2.6pg/ml respectively. CONCLUSION: TNF-alpha levels in midtrimester amniotic fluid do not correlate with pregnancies complicated by preterm labor, preeclamsia, and IUGR different from the third trimester(p=0.06).

Key Words: TNF-alpha, Amniotic fluid, Midtrimester, Pregnancy outcome