A Case Successive Ovulation Induction with an Extended Therapy of Clomiphene in a Patient with Clomiphene-resistant Anovulatory Disorders.

Goh, Seung Hee; Hwang, Jung Hye; Kim, Seung Ryong; Moon, Young Jin; Yoo, Jung Bae; Lee, Jae Auk; Moon, Hyung; Hwang, Youn Yeoung

Case Report

Korean Journal of Obstetrics & Gynecology 1997;40(7):1496-1501.
Published online January 1, 2001.

A Case Successive Ovulation Induction with an Extended Therapy of Clomiphene in a Patient with Clomiphene-resistant Anovulatory Disorders.

Seung Hee Goh, Jung Hye Hwang, Seung Ryong Kim, Young Jin Moon, Jung Bae Yoo, Jae Auk Lee, Hyung Moon, Youn Yeoung Hwang

Department of Obstetrics and Gynecology, School of Medicine, Hanyang University, Seoul, Korea.

Abstract

Clomiphene citrate is the simplest and least expensive from of ovulation induction therapy. In most cases, women who fail to ovulate in response to maximal doses of clomiphene became candidates for treatment with gonadotropins or pulsatile GnRH. Recently, as an alternative to the use of gonadotropins and ovarian surgery, there are some studies of the effectiveness of extended duration clomiphene among the anovulatory women who were resistant to a standard 5-day course of treatment with clomiphene. We have experienced a case of successive ovulation induction and pregnancy with an extended 10-day course of clomiphene in women with clomiphene-resistant anovulatory disorders and reproted with brief reviews of related literatures.

Key Words: Clomiphene citrate, Anovulation, Extended therapy of clomiphene