A Case of Angiomyofibroblastoma of the Vulva.

Lee, Hoo Hyung; Oh, Dae Sik; Yoon, Man Soo; Kim, Won Whe

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Obstet Gynecol Sci > Volume 40(9); 1997 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 1997;40(9):2077-2081.
Published online January 1, 2001.

A Case of Angiomyofibroblastoma of the Vulva.

Hoo Hyung Lee, Dae Sik Oh, Man Soo Yoon, Won Whe Kim

Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Pusan, Korea.

Abstract

Angiomyofibroblastoma is a recently described mesenchymal tumor characterized by unique morphologic features, a propensity to arise in the vulva, and a non-aggressive beni-gn biologic behavior. It is typically well circumscribed and superficially located tumor and its cellularity is variable with hypercellular and hypocellular areas composed of bland-looking, pump stromal cells showing the immunophenotype of vimentin-/desmin - positive, and muscle specific actin(MSA)-/alpha-smooth muscle actin(ASMA) - negative. Spindle or plasm-acytoid cells are the characteristic cell types of most tumors. It is similar to an aggressive pelvic angiomyxoma in histology. Because of histologic similarity and differences in the clinical course and treatment, distinction from aggressive angiomyxoma was needed. It rep-resents new type in the expanding spectrum of tumors of which myofibroblasts constitute an integral component. We experienced a case of angiomyofibroblastoma of the vulva occuring in a 42 years old woman. The lesion was relatively well encapsulated mass(3 X 1.5 X 0.9 cm in dimension), showing intimate admixture of hypercellular and hypocellular area. The tumor contained prominent, somewhat ectatic vessels surrounded by smooth muscle cells, some of which blend or fan out from the muscular walls of the vessels. The margin was relatively free from tumor cells. At immunohistochemical stain, vimentin and desmin was diffuse and weak positive, smooth muscle actin was very a few and weak positive in tumor cells.

Key Words: Angiomyofibroblastoma, Aggressive angiomyxoma, Vulvar mass

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