A Case of Angiomyofibroblastoma of the Vulva.

Lee, Hoo Hyung; Oh, Dae Sik; Yoon, Man Soo; Kim, Won Whe

Search: Korean J Obstet Gynecol Search

CLOSE

Case Report

Korean Journal of Obstetrics & Gynecology 1997;40(9):2077-2081.
Published online January 1, 2001.

A Case of Angiomyofibroblastoma of the Vulva.

Hoo Hyung Lee, Dae Sik Oh, Man Soo Yoon, Won Whe Kim

Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Pusan, Korea.

Abstract

Angiomyofibroblastoma is a recently described mesenchymal tumor characterized by unique morphologic features, a propensity to arise in the vulva, and a non-aggressive beni-gn biologic behavior. It is typically well circumscribed and superficially located tumor and its cellularity is variable with hypercellular and hypocellular areas composed of bland-looking, pump stromal cells showing the immunophenotype of vimentin-/desmin - positive, and muscle specific actin(MSA)-/alpha-smooth muscle actin(ASMA) - negative. Spindle or plasm-acytoid cells are the characteristic cell types of most tumors. It is similar to an aggressive pelvic angiomyxoma in histology. Because of histologic similarity and differences in the clinical course and treatment, distinction from aggressive angiomyxoma was needed. It rep-resents new type in the expanding spectrum of tumors of which myofibroblasts constitute an integral component. We experienced a case of angiomyofibroblastoma of the vulva occuring in a 42 years old woman. The lesion was relatively well encapsulated mass(3 X 1.5 X 0.9 cm in dimension), showing intimate admixture of hypercellular and hypocellular area. The tumor contained prominent, somewhat ectatic vessels surrounded by smooth muscle cells, some of which blend or fan out from the muscular walls of the vessels. The margin was relatively free from tumor cells. At immunohistochemical stain, vimentin and desmin was diffuse and weak positive, smooth muscle actin was very a few and weak positive in tumor cells.

Key Words: Angiomyofibroblastoma, Aggressive angiomyxoma, Vulvar mass

TOOLS

Full text via DOI
Download Citation

Share :

METRICS

776 View
10 Download

Related articles in Obstet Gynecol Sci

A case of huge endometrial cyst of the ovary.1991 February;34(2)

A case of endometrial stromal sarcoma.1991 April;34(4)

A case of leiomyosarcoma of the broad ligament.1991 August;34(8)

Immature teratoma of the ovary.1991 November;34(11)

A case of mixed germ cell tumor of the ovary.1991 December;34(12)

ABOUT

ARTICLE & TOPICS

Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES

POLICY

FOR CONTRIBUTORS

Editorial Office: 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea.
Tel: +82-2-2266-7238 Fax: +82-2-3445-2440 E-mail: journal@ogscience.org