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Korean Journal of Obstetrics & Gynecology 1997;40(10):2204-2210.
Published online January 1, 2001.
Sonographic and Endocrinologic Evaluation of the Patients with Polycystic Ovaries by Body Mass Index.
Jae Sook Roh, Jung Bae Yoo, Jung Hyeu Hwang, Moon Il Park, Soo Hyun Jo, Hyung Moon, Yoon Yeong Hwang
1Department of Obstetrics and Gynecology, College of Medicine, Chungbuk National University, Cheongju, Korea.
2Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul, Korea.
Abstract
Women with Polycystic ovaries(PCO) are often overweight and obesity has been regarded as a possible basis for the development of PCO. This study was designed to evaluate the differences of the basic hormonal concentrations and sonographic features in obese and non-obese patients with PCO. We prospectively analysed eighty-six patiens with PCO on transvaginal sonography and twelve control women with regular menstrual cycle and ovarian morphology from Feb. 1994 to May 1996. Eighty-six women with PCO, of whom sixty-seven women were non -obese with body mass index(BMI) of < or =25(=group 1) and nineteen were obese with BMI >25(=group 2). Sonographic morphology of ovary was evaluated in PCO. Basal concent- rations of LH, FSH, estrone, estradiol, testosterone(T), prolactin, TSH and sex hormone- binding globulin(SHBG) in serum were measured. Although sonographic morphology of ovary was not significantly different between group 1 and group 2, number of small follicles was tend to increase in group 2. The LH/ FSH ratio was significantly higher in group 1 compared to group 2, but SHBG was higher in group 2. Conclusively, in obese women, obesity causes an increase in free androgen through the decrease in SHBG, which might cause a disturbance in gonadotropin secretion leading to the typical changes of polycystic ovary. In non-obese women, relative increase of LH/FSH ratio stimulates excessive production of androgen.
Key Words: Polycystic ovary, Body mass indes, Sonography, Gondadotropin, Androgen


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