| Prognostic Significance of Bcl-2 Expression in Ovarian Cancers. |
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Gu Kong, Young Ha Oh, Chan Pil Park, Do Soo Nah, Yung Jin Moon, Kyung Tai Kim, Youn Yeoung Hwang, Jung Dal Lee |
1Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.
2Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul, Korea.
3Department of Pathologyc, Kangbuk Samsung Hospital, Samsung Medical Center, Korea. |
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| Abstract |
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The protein encoded by the Bcl-2 proto-oncogene has been shown to prolong cell su-rvival by preventing cell death(Apoptosis) induced by many insults including cancer therap-eutic drugs. Recently many researches have elucidated the bcl-2 expression in several hu-man solid cancers. However, there is still a few avaiable data to determine the role of Bcl-2 expression in the ovarian carcinogenesis and its prognostic significance in ovarian can-cers. Hence, we examined the expression of Bcl-2 in 68 ovarian epithelial cancers using immunohistochemistry and determined whether Bcl-2 expression has prognostic significance in the ovarian epithelial cancers. We found Bcl-2 expression(>5% positive cell) in 31 patients(40%). Bcl-2 expression were exclusively negative in the mucinous type of the ovarian epithelial cancer. Bcl-2 exp- ression was not correlated with tumor stage(stage I & II vs III & IV, p=0.63). The patients with Bcl-2 positivity had lower recurrence rate than the patients with negativity at the se- cond look operation(p<0.01). Although there was a trend that the patients with Bcl-2 posi- tivity had better acturial survival than the patient with negativity, the stastical significance was not present(3 years acturial survival;+vs-;63%, 29%;p>0.05). These results sug- gest the Bcl-2 expression appears an early event in the ovarian carcinogenesis and has an inhibiting role in progression of ovarian tumor. |
| Key Words:
Bcl-1 expression, Ovarian cancer, Recurrence and prognosis, Immunohistochemitry |
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