| The association of serum placental growth factor with pregnancies complicated by preeclampsia and small for gestational age. |
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Je Yeon Lee, Ga Young Yang, So Yeon Park, Ki Sook Hong, Se Jin Oh, Mi Hye Park, Sun Hee Chun, Young Ju Kim |
1Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea. kkyj@ewha.ac.kr
2Department of Laboratory Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
3Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea. |
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| Abstract |
OBJECTIVE
Placental growth factor (PlGF) is one of the many angiogenic factors, which is decreased in placenta and serum during preeclampsia (PE) and also associated with pregnancies complicated by small for gestational age. In this study, we compared serum PlGF levels with different groups (controls, PE patients, pregnant women with small for gestational age [SGA]) and evaluated the usefulness of PlGF for diagnosis. METHODS: Serum samples were collected at the time of delivery from 40 women with uncomplicated pregnancies, 30 women with PE, 30 women with pregnancies complicated by SGA fetuses. Serum PlGF level was measured in all the samples using Triage PlGF test. We used the Kruskal-Wallis test and receiver operator characteristic curve analysis. RESULTS: Maternal serum PlGF concentrations in pregnancies complicated by PE (21.17 +/- 15.27 pg/mL) were significantly lower than those in uncomplicated pregnancies (133.70 +/- 158.80 pg/mL, P<0.01) and PlGF concentrations were decreased in pregnancies complicated by SGA fetuses (95.65 +/- 210.36 pg/mL) compared with control group, but there was no statistically significant difference. CONCLUSION: Decreased PlGF concentrations were observed in pregnancies complicated by PE and SGA. PlGF concentrations in pregnancies complicated by PE was significantly lower than those in uncomplicated pregnancies. By further prospective investigation, we may expect that the PlGF levels during pregnancy will be a marker to identify women at risk for the development of PE and SGA. |
| Key Words:
Pre-eclampsia, Small-for-gestational age, Placental growth factor |
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