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Korean Journal of Obstetrics & Gynecology 1998;41(5):1268-1272.
Published online January 1, 2001.
Insulin-like Growth Factor Binding Protein-1 ( IGF-BP-1 ) in Maternal Serum of Women with Pregnancy Induced Hypertension.
Y K Yoo, J S Cho, H M Choi, Y H Lee, Y W Park
IGF-BP-1 is known to have a important role in fetal growth and development by modulation of the actions of IGF, but also has its independent actions and in vitro IGF- BP-1 inhibits cytotrophoblastic invasion into decidualized stromal multilayers. The goals of this study are to investigate the IGF-BP-1 in maternal serum of women with pregnancy induced hypertension and without and evaluate the relationship between IGF-BP-1 of maternal serum and intrauterine growth restriction. IGF-BP-1 levels in maternal serum with pregnacy induced hypertension were 183.5+/-46.3 ng/ml compared with 148.9+/-44.3 ng/ml in controls (p<0.01). IGF-BP-1 levels in maternal serum with pregnancy induced hypertension and intrauterine growth restriction were 199.1+/-44.8 ng/ml compared with 167.1+/-42.2 ng/ml in maternal serum with pregnancy induced hypertension but without intrauterine growth restriction. In conclusion, elevated maternal serum IGF-BP-1 levels may contribute to restricted placental and therefore fetal growth.
Key Words: IGF-BP-1, Pregnancy induced hypertension, Intrauterine growth restriction

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