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Korean Journal of Obstetrics & Gynecology 1998;41(8):2084-2088.
Published online January 1, 2001.
Presence of E-Cadherin and its Messenger Ribonucleic Acid in Leiomyoma and Myometrium.
K H Lee, K C Kang
Abstract
Cell adhesion molecules (CAMs) may be categorized into cadherins, integrins, the immunoglobulin superfamily and others. E-cadherin, a calcium-dependent cell adhesion molecule, is a 120 kDa transmembrane glycoprotein that is localized in the adherens junction of epithelial cells. These molecules are key mediators in cell motility and tissue integrity. E-cadherin interacts with the cytoskeleton through the associated cytoplasmic catenin proteins and is also a critical regulator of epithelial junction formation. They mediate cell-cell adhesion mainly by homotypic interaction, although heterotypic binding between different cadherin molecules is possible. Leiomyoma and adjacent myometrium were examined for the presence and expression of E-cadherin and its messenger ribonucleic acid (mRNA) from 9 women through the menstrual cycle. On the immunohistochemistry, E-cadherin was abundantly showed on the cytoplasm of the cells. Western ligend blotting showed clear 120 kDa bands in all the tissues. However there were no significant differences of relative abundance between the tissues and also there were no differences between the stage of menstrual cycles. RT-PCR of the tissues showed 431 bp bands.
Key Words: E-cadherin, Leiomyoma, Myometrium, messenger ribonucleic acid


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