Serum Concentration of CA-125 during the First Trimester of Normal and Abnormal Pregnancies.

Ro, Duck Yeong; Kim, Do Kang; Kim, Soo Pyung; Moon, Hee Bong; Kang, Gyu Sub; Hwang, Jee Young; Shin, Bong Young; Jang, Byeung Woo

Original Article

Korean Journal of Obstetrics & Gynecology 1998;41(11):2776-2779.
Published online January 1, 2001.

Serum Concentration of CA-125 during the First Trimester of Normal and Abnormal Pregnancies.

Duck Yeong Ro, Do Kang Kim, Soo Pyung Kim, Hee Bong Moon, Gyu Sub Kang, Jee Young Hwang, Bong Young Shin, Byeung Woo Jang

Abstract

A prospective study was initiated to compare maternal serum concentration of CA-125 during the first trimester of normal and abnormal pregnancies. Serum specimens were obtained from 87 women with a normal intrauterine pregnancy and 47 women with abnormal pregnancies which were ended in spontaneo abortion or pathologically confirmed to be missed abortion. In normal pregnancies, the mean serum CA-125 concentrations were increased significantly from amenorhea 6 weeks (139.838.7 IU/ml), and were higher statistically than the values tested in the same weeks of abnormal pregnancies. In abnormal pregnancies serum CA-125 concentations were relatively lower than those of normal pregnancies. But these differences were not statistically significant except the values tested in amenorhea 6weeks. So serum levels of CA-125 may not be proved useful in monitoring of early pregnancies outcome.

Key Words: CA-125, Early pregnancy