A Case of Successful Pregnancy in a Woman with Anti-M Isoimmunization after Intravenous Immunoglobulin Therapy.

Jun, Jong Young; Noh, Keun Woong; Cho, Dong Hee; Kim, Eun Sung; Ryu, Hyun Mee; Kim, Moon Young

Case Report

Korean Journal of Obstetrics & Gynecology 1998;41(11):2895-2897.
Published online January 1, 2001.

A Case of Successful Pregnancy in a Woman with Anti-M Isoimmunization after Intravenous Immunoglobulin Therapy.

Jong Young Jun, Keun Woong Noh, Dong Hee Cho, Eun Sung Kim, Hyun Mee Ryu, Moon Young Kim

Abstract

Although severe hemolytic diseases of the newborn triggered by anti-M are very rare, anti-M alloantibodies have been known to be associated with a cause of multipie intrauterine death. Serological and hematological investigations have been reported on a woman who experienced four multiple intrauterine deaths due to anti-M. The mothers blood type was of group A, NN and the husbands cells were of group B, MN. In the serological examination at 9th week's gestation of the fifth pregnancy, anti-M antibodies were identified in her serum. The antibodies comprised IgM saline agglutinin at a titer of 16 at 4 degrees C and IgG agglutinin reacted in an indirect antiglobulin technique at a titer of 4 at 37 degrees C. She underwent high-dose immunoglobulin infusion therapy on a monthly program from 3rd month gestation and a total of 6 times of intravenous immunoglobulin was given. The anti-M titer did not rise during the pregnancy. She delivered a live girl by cesarean section at the 37th week because of a failure of induction. The childs blood type was of group O, MN. The child was discharged and developed normally.

Key Words: Anti-M isoimmunization, Pregnancy, Intravenous immunoglobulin