Prenatal Cytogenetic Analysis of 145 Fetuses Conceived by Intracytoplasmic Sperm Injectiion ( ICSI ).

Lee, Sook Hwan; Oum, Ki Boong; Lee, Eun Jung; Yoon, Tae Ki; Cha, Kwang Yul; Kwak, In Pyung; Choi, Dong Hee

Obstet Gynecol Sci > Volume 41(12); 1998 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 1998;41(12):3040-3043.
Published online: January 1, 2001

Prenatal Cytogenetic Analysis of 145 Fetuses Conceived by Intracytoplasmic Sperm Injectiion ( ICSI ).

Sook Hwan Lee, Ki Boong Oum, Eun Jung Lee, Tae Ki Yoon, Kwang Yul Cha, In Pyung Kwak, Dong Hee Choi

Abstract

Prenatal diagnoses were performed in 145 fetuses resulting from 73 singleton and 36 twin pregnancies, all established by intracytoplasmic sperm injection (ICS: amniocentesis in 108 patients and Chorionic villus sampling in one. The prenatal cytogenetic results were obtained from pregnancies after ICSI using ejaculated spermatozoa, epididymal spermatozoa, testicular spermatozoa and after the replacement of frozen-thawed embryos derived from ICSI. The Karyotypes were normal in 138 cases (95.2%) of the prenatal diagnoses and there were 2 cases (1.4%) de novo and 5 cases (3.4%) inherited chromosomal aberrations. The two cases of de novo abnormalities were: 46, XY, t(6;7)(q21;p22) and 47, XY, +21 (trisomy 21).

Keywords: Intracytoplasmic sperm injection (ICSI); Prenatal diagnoses; Chromosomal aberrations