A Case Report of Distant Metastatic , Recurrent Ovarian Cancer , Markedly  Responded to Hexamethylmelamine and Tamoxifen as A Second-line Salvage  Chemotherapy.

Lee, J R; Kim, S R; Song, E S; Koh, S K; Lim, Y G; Hwang, S W; Cho, S; Lee, W Y

Case Report

Korean Journal of Obstetrics & Gynecology 1999;42(5):1102-1107.
Published online January 1, 2001.

A Case Report of Distant Metastatic , Recurrent Ovarian Cancer , Markedly Responded to Hexamethylmelamine and Tamoxifen as A Second-line Salvage Chemotherapy.

J R Lee, S R Kim, E S Song, S K Koh, Y G Lim, S W Hwang, S Cho, W Y Lee

Abstract

An advanced, recurrent epithelial ovarian cancer that had metastasized to the liver, spleen and pelvic cavity after secondary debulking surgery and first-line salvage chemotherapy, was treated with hexamethylmelamine [260 mg/m2, orally daily] and tamoxifen [20 mg orally twice daily] as a second-line salvage therapy. After 3 courses of a salvage chemotherapy, the metastatic lesions of the liver and spleen were nearly disappeared and the metastatic pelvic mass was not discovered on the abdomino-pelvic CT. This case represents our experience that hexamethylmelamine and tamoxifen can provide one of the salvage regimens to a selected patient with a advanced, metastatic ovarian cancer.

Key Words: Ovarian cancer, salvage chemotherapy, hexamethylmelamine