Korean J Obstet Gynecol Search


Korean Journal of Obstetrics & Gynecology 1999;42(7):1457-1464.
Published online January 1, 2001.
Estradiol Supplement Therapy during Controlled Ovarian Hyperstimulation in Patients of IVF-ET with Thin Endometrium.
K S Han, H C Kwon, K J Hwang, C H Lee, J I Yang, M R Kim, K S Oh
To evaluate the endometrial response and the receptivity of estradiol supplement in patients with abnormally thin endometrium who were undergoing IVF-ET. METHODS: Design: A prospective, nonrandomized study. Setting: Ajou University School of Medicine, Suwon, Korea. Patients: A total of 772 IVF-ET cycles divided into four groups by endometrial thickness on the day of hCG injection and applied protocols. Interventions: Estradiol supplement before/during COH using GnRH agonist long protocol in patients with less than 7mm endometrial thickness from the previous cycle on the day of hCG administration. Main Outcome Measures: Incidence of patients with improved endometrial thickness 7mm, quality of transferred embryos and pregnancy rate were compared. Result[s]: Patients with thin endometrium [<7mm] in their previous cycle had a 74.1% [20/27] chance in cycles with estradiol supplement before/during COH to develop optimal endometria more than 7mm comparable to a 78.3% [18/23] chance in subsequent cycles of long term estrogen replacement. The pregnancy rate was markedly improved after the treatment protocol[9.5% vs. 30.7%]. Conclusion[s]: In cases where the endometrium is not adequate in the previous cycle, it is suggested that estradiol supplement before/during COH using GnRH agonist long protocol is effective.
Key Words: Thin endometrium, Estradiol supplement

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