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Korean Journal of Obstetrics & Gynecology 1999;42(7):1539-1544.
Published online January 1, 2001.
The Effect of Treatment with Low-dose Aspirin in the Mild Preeclamptic Patients in the Third Trimester of Pregnancy.
S Y Jung, M D Seo, Y H Lee, J S Lee, C M Lee, Y W Kim
Low-dose aspirin therapy is recommended as prophylaxis in women at high risk for preeclampsia. This study made to determine whether low-dose aspirin reduces the number of women who develope to severe preeclampsia, and whether it reduces perinatal mortality and improves birth weights in pregnant women who develope the symptom and sign of the mild preeclampsia. METHODS: Ninety-four patients were recruited from the antenatal clinics at Gil medical center with mid preeclampsia at 28 to 36 weeks gestation and were randomized to receive either 60mg of aspirin or none. RESULTS: The mean blood pressure values [systolic 153.13+/-1 vs 150.65+/-1 mmHg, diastolic 101.67+/-7 vs 99.78+/-8 mmHg], the rates of development of severe preeclampsia [37.5% vs 34.8%], the gestational ages at delivery [36.0+/-2.7 vs 36.7+/-2.1 weeks], newborn body weights [2311+/-733 vs 2415+/-505 gm], 5-minute Apgar scores [8.1+/-2 vs 8.2+/-2], and fetal growth retardation[41.7% vs 41.3%] were similar in the low-dose aspirin treated and the control groups. CONCLUSIONS: We conclude that low-dose aspirin is not curative in reducing development of severe preeclampsia and in lowering fetal growth retardation, but it is essential to a preventive treatment for high risk patients which, in order to be effective, should be started weeks before clinical signs of preeclampsia are present.
Key Words: Low-dose aspirin, Preeclampsia, Fetal growth retardation

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