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Korean Journal of Obstetrics & Gynecology 1999;42(9):1909-1913.
Published online January 1, 2001.
Umbilical Vein Serum Nitric Oxide Concentration and Fetal Growth Restriction in Preeclampsia.
Moon Seok Cha
Abstract
OBJECTIVE
To evaluate the role of nitric oxide(NO) in fetal growth. METHOD: We measured umbilical vein serum NO in preeclampsia by Stuehr method and evaluated the association with the fetal birth weight and compared with normal pregnancy and twin pregnancy. RESULTS: 1. The umbilical vein serum nitrite concentration in preeclampsia was higher than that of the normal pregnancy (p<0.005). 2. Umbilical vein serum nitrite concentration of FGR(fetal growth restriction) baby group was higher than that of the non-FGR group in preeclampsia (p<0.005). 3 Umbilical vein serum nitrite concentration of larger baby group was higher than that of the smaller baby group in twin pregnancy but statistically not significant (p>0.005). 4. There were no significant differences of umbilical vein serum nitrite concentration between twin pregnancy and normal single pregnancy group (p>0.005). CONCLUSION: These results suggest that the increased nitric oxide production in the umbilical vein may be a compensatory response to improve blood flow and fetal growth in preeclampsia.
Key Words: Nitric oxide, Umbilical vein, Preeclampsia, Fetal growth restriction, NO(nitric oxide)


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