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Korean Journal of Obstetrics & Gynecology 1999;42(9):2126-2131.
Published online January 1, 2001.
A Case of Complete Response in Locally Advanced Vulvar Cancer after Concomitant Chemoradiation Therapy.
Soo Yeon Han, Noh Hyun Park, Hong Gyun Wu, Ju Weon Roh, Hyeon Jeong Jeong, Jae Weon Kim, Yong Sang Song, Soon Beom Kang, Hyo Pyo Lee
Cancer of the vulva accounts for approximately 0.5% of all gynecologic malignancies. At diagnosis, one-third of these cases is detected in an advanced stage (FIGO stages III, IV), and local extension of primary vulvar cancer may involve adjacent midline structures such as the clitoris, urethra, vagina, and anus. Initial surgical therapy of such locally advanced primary cancers may compromise the functional integrity of midline structures, necessitating ultraradical surgery including pelvic exenteration. In view of the relatively elderly age of the patients and the morbidity of this ultraradical dissection, concomitant chemoradiation therapy - that the efficacy had been proven in head and neck cancer, anal cancer has approached for patients with locally advanced vulvar cancer. We experienced a case of stage III vulvar cancer patient, who underwent concomitant chemoradiation therapy with 5-fluorouracil(FU) and cisplatin and who showed complete response. So, we report this case with brief review of the literatures.
Key Words: Locally advanced vulvar cancer, Concomitant chemoradiation therapy

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