The clinical study of 37 pregnancy women with aplastic anemia.

Lee, Keun Ho; Lee, Jong Kun; Yoo, Jin Hee; Lee, Jee Hyun; Jo, Hyeong Kwon; Lee, Ji Young; Kim, Seung Jo; Kim, Soo Pyung

Obstet Gynecol Sci > Volume 42(11); 1999 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 1999;42(11):2536-2541.
Published online January 1, 2001.

The clinical study of 37 pregnancy women with aplastic anemia.

Keun Ho Lee, Jong Kun Lee, Jin Hee Yoo, Jee Hyun Lee, Hyeong Kwon Jo, Ji Young Lee, Seung Jo Kim, Soo Pyung Kim

Abstract

Objectives
To determine whether the clinical aspect of aplastic anemia is influenced by pregnancy. METHODS: We reviewed 37 cases of pregnant aplastic anemia patients during Jan. 1989 to Dec. 1998, and examined age, parity, progress of pregnancy, termination methods, obstetrics & neonatal complications, hematologic change, and treatment modality by medical records. RESULTS: According to onset of disease, patients were divided into pre-pregnant diagnosed group(n=12) and during-pregnancy diagnosed group(n=25). Mean age of diagnosis was 29.4yr, 89.2% were nulliparous, and 51.4% were severe aplastic anemic patients. All patients underwent 50 pregnancy. Mean gestational period was 37wks, birth weight was 2569gram, and, except in 7 cases of abortion, 43 cases were delivered transvaginally or transabdominally(51.2% vs. 48.8%). Preeclampsia, eclampsia, preterm labor, restricted growth, and distress were complicated and decreased hemoglobin, hematocrit, reticulocyte, platelet were reversed after termination in pregnancy associated group. Treatment modality during pregnancy included transfusion, steroid, anti-lymphocytic globulin, anti-thymocytic globulin and IVGV, and remission rate was 45.5% in pregnancy associated group. CONCLUSION: We concluded that pregnancy is associated with aplastic anemia as a high risk factor, and intensive treatment is needed.

Key Words: Pregnancy, Aplastic anemia