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Korean Journal of Obstetrics & Gynecology 2000;43(4):611-615.
Published online January 1, 2001.
Cyclooxygenase - 2 Expression in Cervical Intraepithelial Neoplasia and Cervical Cancer.
Woo Seok Sohn, Sung Joo Kim, Li Hao Liu, Bum Kim, Je Yong Park, Jung Bae Kang, Hye Rim Park, Pong Rheem Jang
Abstract
OBJECTIVE
A large body of evidence suggests that cyclooxygenase-2(COX-2) is important in tumorigenesis of gastrointestinal cancer. The purpose of this study was to determine whether COX-2 was also expressed in cervical intraepithelial neoplasia(CIN) and invasive cervical carcinoma. METHODS: We studied the expression of COX-2 in normal cervix(n=6), CIN I(n=4), CIN II(n=2), CIN III(n=15), microinvasive carcinoma(n=5) and invasive carcinoma(n=7) by immunohistochemistry. RESULTS: We observed strong COX-2 expression in 16.7% of the normal cervix, 0% of the CIN I and II, 80.0% of CIN III, 60.0% of microinvasive carcinoma and 71.4% of invasive carcinoma. The intensity of immunostaining was stronger in the CIN III and invasive cancer than the normal cervix and CIN I lesions(p<0.01). CONCLUSION: These results suggest that COX-2 may have a role in carcinogenesis of CIN and may be a target for the prevention or treatment of CIN and invasive cervical cancer.
Key Words: Cyclooxygenase-2, CIN, Cervical cancer


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