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Korean Journal of Obstetrics & Gynecology 2000;43(6):1043-1050.
Published online January 1, 2001.
Attenuation of endothelial relaxation in umbilical arteries from preeclampsia patients.
Sei Kwang Kim, Hyung Min Choi, Yong Won Park, Jae Wook Kim, Duck Sun Ahn, Bok Soon Kang
Abstract
OBJECTIVES
AND METHODS: To directly examine the function of the endothelial cell(EC) and smooth muscle cell in umbilical arteries acquired from preeclampsia patients between June 1998 to November 1999, using a conventional tension measurement and bioassay experiment. RESULTS: Relaxation responses to EC-dependent relaxing agents including bradykinin and A23187 in human umbilical artery rings were significantly decreased in preeclampsia(p<0.01). Relaxation responses to EC-independent agents(SNP and SNAP) were also inhibited in umbilical artery rings acquired from preeclampsia patients(p<0.01). To test the change of endothelial cell function in preeclampsia without involvement of smooth muscle dysfunction, we used human umbilical artery and rabbit femoral artery as a donor and detector, respectively, in bioassay experiment. Relaxation responses to EC-dependent agents(A23187 and bradykinin) showed similar results to conventional tension measurement (p<0.01). Relaxation responses to 8-bromo-cGMP in human umbilical artery rings were also significantly decreased in preeclampsia(p<0.01). CONCLUSIONS: It can be concluded that increased vascular resistance in preeclampsia is not only due to the disturbance of endothelial function, but also to smooth muscle dysfunction.
Key Words: Preeclampsia, Umbilical artery, Vasoactive substance, Endothelial cell dependent relaxation(EDR), Endothelial cell independent relaxation


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