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Korean Journal of Obstetrics & Gynecology 2000;43(6):1114-1118.
Published online January 1, 2001.
A Case Report of Vertebral Artery Aneurysm and Preeclampsia Complicating a Pregnancy with Neurofibromatosis.
Young Mi Oh, Min Suk Koh, Jung Eun Yeu, Chang Sue Park, Sung Jin Cho
Neurofibromatosis is a complex hereditary disease involving many organs and systems. The incidence in pregnancy is less frequent and has been reported as 1/5000 to 1/18500 deliveries. Therefore, little is known about the interactions between neurofibromatosis and pregnancy. A survey of relevant literature suggests that patients with NF have an increased risk of perinatal complications (pregnancy induced hypertension, IUGR, preterm labor, abortion, stillbirth, high cesarean section rate) and maternal disease aggravation (rupture of an aneurysm, sarcomatous degeneration of neurofibroma, activation of pheochromocytoma). Refined ultrasound, flow studies and fetal monitoring allow us to provide improved pregnancy care for neurofibromatosis. However, It should be remembered that even now, neurofibromatosis places pregnant women and their fetuses in a high risk group with the potential to develop life threatening complications. We report a case of vertebral artery aneurysm and preeclampsia complicating a pregnancy with neurofibromatosis."
Key Words: neurofibromatosis, aneurysm, preeclampsia

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