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Korean Journal of Obstetrics & Gynecology 2000;43(7):1144-1146.
Published online January 1, 2001.
Molecular variants of the FSH receptor exon 10 (Thr307Ala; A919G) in premature ovarian failure (POF) women by PCR-SSCP.
Nam Keun Kim, Sook Hwan Lee, Yoon Sung Nam, Tae Jong Sohn, Sang Hee Park, Chan Park, Jung Jae Ko, Kwang Yul Cha
Abstract
OBJECTIVE
This study was performed to determine whether the FSH receptor mutation is present in infertile Korean patients with 46,XX premature ovarian failure (POF) women. METHODS: The variant of FSH receptor exon 10 in thirteen 46, XX idiopathic POF and 4 healthy fertile (control) women were studied. Missense mutation in Exon 10 was detected in POF patients and healthy fertile women by polymerase chain reaction-single stranded conformation polymorphism (PCR-SSCP). RESULTS: The variant types of FSH receptor exon 10 (Thr307Ala; A919G) were found in healthy fertile (control) and POF women. CONCLUSIONS: This mutation may not be specific in POF patients and further study is needed in fertile (control) and POF women.
Key Words: Premature ovarian failure (POF), FSH receptor gene, Missense mutation, PCR-SSCP
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