A Case of Complete Remission of Choriocarcinoma with Brain Metastases Treated with Multicycle High-dose MTX/EMA-CO, Intrathecal MTX and Whole Brain RT.

Chun, Eun Gyung; Rho, Joo Won; Seo, Sang Soo; Yoon, Hyung Dong; Kim, Jae Won; Park, No Hyun; Song, Yong Sang; Kang, Soon Bum; Lee, Hyo Pyo

Case Report

Korean Journal of Obstetrics & Gynecology 2001;44(1):189-193.
Published online January 1, 2001.

A Case of Complete Remission of Choriocarcinoma with Brain Metastases Treated with Multicycle High-dose MTX/EMA-CO, Intrathecal MTX and Whole Brain RT.

Eun Gyung Chun, Joo Won Rho, Sang Soo Seo, Hyung Dong Yoon, Jae Won Kim, No Hyun Park, Yong Sang Song, Soon Bum Kang, Hyo Pyo Lee

Department of Obststrics and Gynecology, College of Medicine, Seoul national university, seoul, Korea.

Abstract

Patients of choriocarcinoma with brain metastases are considered to have a very poor prognosis due to chemo-refractoriness and recurrence. So, selection and individualization of patients then followed by multimodality therapy are very important. We present a case of a patient who experienced twice of craniotomies due to intracranial hemorrhage and an emergent explorative laparotomy due to intestinal perforation of the metastatic sites of choriocarcinoma. She was treated with 12 cycles of high-dose MTX/EMA-CO, intrathecal MTX and WBRT. Eventually she has obtained a complete remission that ongoing for 2 years. So, we report this case with a brief review of the literatures.

Key Words: Choriocarcinoma with brain metastases, High-dose MTX/EMA-CO, Intrathecal MTX, Whole brain radiation therapy