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Korean Journal of Obstetrics & Gynecology 2001;44(2):296-301.
Published online February 1, 2001.
The Concentration of Estradiol, Testosterone and Insulin-like Growth Factor-I in Follicular Fluid of Patients with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation.
Sung Hoon Kim, Hye Eun Kwon, Eun Ju Park, Hee Dong Chae, Chung Hoon Kim, Byung Moon Kang, Yoon Seok Chang
Division of Rep roductive Endocrinology and Inf ertility, Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Abstract
OBJECTIVE
To evaluate microenvironment of follicular fluid, such as estradiol(E2), testosterone(T), and insulin-like growth factor-I(IGF-I) of patients with polycystic ovary syndrome(PCOS) undergoing controlled ovarian hyperstimulation(COH) for in vitro fertilization and embryo transfer(IVF-ET). MATERIALS AND METHODS: From January 1996 to June 1998, follicular concentrations of E2, T, and IGF-I on the day of transvaginal ovum aspiration were measured in 40 patients undergoing COH for IVF-ET. The patients were grouped into the control(n=20) and the PCOS(n=20) groups. Statistical analysis was performed using Student's t-test, Fisher's exact test, and X2 test as appropriate. Statistical significance was defined as p<0.05. RESULTS: There were no significant differences in the follicular concentrations of E2, T, and IGF-I between the control and the PCOS groups. CONCLUSION: IGF-I might be not a main component of the local regulatory mechanisms involved in the pathogenesis of PCOS.
Key Words: Polycystic ovarian syndrome, Follicular fluid, Insulin-like growth factor-I, Estrogen, Testosterone


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