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Korean Journal of Obstetrics & Gynecology 2001;44(2):405-408.
Published online February 1, 2001.
A Case of premature ovarian failure developed from oral medication of cyclophosphamide for the treatment of pemphigus vulgaris.
Youn Joon Sung, Yoon Ho Lee, Dong Hyun Cha, Jung Yeol Kim, Soon Oak Hong
Department of Obstetrics and Gynecology, Yonsei University Medical College, Yongdong Severance Hospital, Seoul, Korea.
Pemphigus vulgaris is autoimmune disease characterized by acantholysis and blister formation in the skin and mucosa. The introduction of corticosteroids has greatly reduced mortality, and a number of immunosuppressive agents, such as azathioprine and cyclophosphamide are recommended as adjuncts to oral steroids. A 38-year-old female patient of pemphigus vulgaris has been managed with daily oral cyclophosphamide as adjunct to prednisolone for about 11 months, and then transfered to our department due to amenorrhea for 4 months. Hormonal profile of FSH, LH and estradiol revealed in postmenopausal range and follow-up results of hormonal profile were not changed, and amenorrhea continues for total 13 months until now. So we report a case of premature ovarian failure complicated by long-term oral administration of cyclophosphamide.
Key Words: Premature ovarian failure, Cyclophosphamide, Pemphigus vulgaris

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